Assoziation zwischen verkürzter Telomerlänge und rheumatoider Arthritis: Eine Metaanalyse

Translated title of the contribution: Association between shortened telomere length and rheumatoid arthritis: A meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA). Methods: We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status. Results: Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = −0.833, 95 % CI = −1.332 to −0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = −1.415, 95 % CI = −1.709 to −1.120, p < 1.0 × 10−8; SMD = −0.658, 95 % CI = −1.187 to −0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = −1.070, 95 % CI = −1.489 to −0.650, p = 5.7 × 10−7; SMD = 0.155, 95 % CI = −0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = −1.033, 95 % CI = −1.398 to −0.768, p < 1.0 × 10−8; SMD = −0.967, 95 % CI = −2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = −0.415, 95 % CI = −0.699 to −0.131, p = 0.004). Conclusions: Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.

Translated title of the contributionAssociation between shortened telomere length and rheumatoid arthritis: A meta-analysis
Original languageGerman
Pages (from-to)1-7
Number of pages7
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2016 Sep 19

Keywords

  • Autoimmune diseases
  • Biological markers
  • Etiology
  • HLA antigens
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology

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