Assoziation zwischen verkürzter Telomerlänge und rheumatoider Arthritis: Eine Metaanalyse

Translated title of the contribution: Association between shortened telomere length and rheumatoid arthritis: A meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA). Methods: We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status. Results: Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = −0.833, 95 % CI = −1.332 to −0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = −1.415, 95 % CI = −1.709 to −1.120, p < 1.0 × 10−8; SMD = −0.658, 95 % CI = −1.187 to −0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = −1.070, 95 % CI = −1.489 to −0.650, p = 5.7 × 10−7; SMD = 0.155, 95 % CI = −0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = −1.033, 95 % CI = −1.398 to −0.768, p < 1.0 × 10−8; SMD = −0.967, 95 % CI = −2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = −0.415, 95 % CI = −0.699 to −0.131, p = 0.004). Conclusions: Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.

Original languageGerman
Pages (from-to)1-7
Number of pages7
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2016 Sep 19

Fingerprint

Telomere Shortening
Meta-Analysis
Rheumatoid Arthritis
Epitopes
Telomere
Control Groups
Research Design
Age Groups

Keywords

  • Autoimmune diseases
  • Biological markers
  • Etiology
  • HLA antigens
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology

Cite this

Assoziation zwischen verkürzter Telomerlänge und rheumatoider Arthritis : Eine Metaanalyse. / Lee, Young Ho; Bae, S. C.

In: Zeitschrift fur Rheumatologie, 19.09.2016, p. 1-7.

Research output: Contribution to journalArticle

@article{d087a05727174bc987eae1a9e68e36a3,
title = "Assoziation zwischen verk{\"u}rzter Telomerl{\"a}nge und rheumatoider Arthritis: Eine Metaanalyse",
abstract = "Objective: This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA). Methods: We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status. Results: Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = −0.833, 95 {\%} CI = −1.332 to −0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = −1.415, 95 {\%} CI = −1.709 to −1.120, p < 1.0 × 10−8; SMD = −0.658, 95 {\%} CI = −1.187 to −0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = −1.070, 95 {\%} CI = −1.489 to −0.650, p = 5.7 × 10−7; SMD = 0.155, 95 {\%} CI = −0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = −1.033, 95 {\%} CI = −1.398 to −0.768, p < 1.0 × 10−8; SMD = −0.967, 95 {\%} CI = −2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = −0.415, 95 {\%} CI = −0.699 to −0.131, p = 0.004). Conclusions: Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.",
keywords = "Autoimmune diseases, Biological markers, Etiology, HLA antigens, Risk factors",
author = "Lee, {Young Ho} and Bae, {S. C.}",
year = "2016",
month = "9",
day = "19",
doi = "10.1007/s00393-016-0209-9",
language = "German",
pages = "1--7",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",

}

TY - JOUR

T1 - Assoziation zwischen verkürzter Telomerlänge und rheumatoider Arthritis

T2 - Eine Metaanalyse

AU - Lee, Young Ho

AU - Bae, S. C.

PY - 2016/9/19

Y1 - 2016/9/19

N2 - Objective: This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA). Methods: We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status. Results: Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = −0.833, 95 % CI = −1.332 to −0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = −1.415, 95 % CI = −1.709 to −1.120, p < 1.0 × 10−8; SMD = −0.658, 95 % CI = −1.187 to −0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = −1.070, 95 % CI = −1.489 to −0.650, p = 5.7 × 10−7; SMD = 0.155, 95 % CI = −0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = −1.033, 95 % CI = −1.398 to −0.768, p < 1.0 × 10−8; SMD = −0.967, 95 % CI = −2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = −0.415, 95 % CI = −0.699 to −0.131, p = 0.004). Conclusions: Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.

AB - Objective: This study aimed to evaluate the relationship between telomere length and rheumatoid arthritis (RA). Methods: We performed a meta-analysis of studies comparing the telomere length in RA patients and healthy controls, and conducted subgroup analysis based on ethnicity, age-matched status, study quality, sample type, assay method, subject number, and shared epitope (SE) status. Results: Nine studies from seven articles, with 388 RA patients and 362 controls, were included. Meta-analysis showed that the telomere length was significantly shorter in all individuals of the RA group than in those of the control group (SMD = −0.833, 95 % CI = −1.332 to −0.334, p = 0.001). Stratification by ethnicity showed significantly shortened telomere lengths in both mixed and age-matched Caucasian populations with RA (SMD = −1.415, 95 % CI = −1.709 to −1.120, p < 1.0 × 10−8; SMD = −0.658, 95 % CI = −1.187 to −0.0.128, p = 0.015). The telomere length was significantly shorter in the RA group than in the age-matched control group; however, this was not the case in the RA group that was not age-matched (SMD = −1.070, 95 % CI = −1.489 to −0.650, p = 5.7 × 10−7; SMD = 0.155, 95 % CI = −0.119 to 0.429, p = 0.267). Stratification by SE status revealed a significantly shortened telomere length in the SE-positive group, but not in the SE-negative group (SMD = −1.033, 95 % CI = −1.398 to −0.768, p < 1.0 × 10−8; SMD = −0.967, 95 % CI = −2.382 to 0.449, p = 0.181). In addition, the telomere length was significantly shorter in the SE-positive RA group than in the SE-negative RA group (SMD = −0.415, 95 % CI = −0.699 to −0.131, p = 0.004). Conclusions: Our meta-analysis demonstrated that the telomere length was significantly shorter in patients with RA, and was significantly more so in the SE-positive group than in the SE-negative group.

KW - Autoimmune diseases

KW - Biological markers

KW - Etiology

KW - HLA antigens

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84988416900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988416900&partnerID=8YFLogxK

U2 - 10.1007/s00393-016-0209-9

DO - 10.1007/s00393-016-0209-9

M3 - Article

AN - SCOPUS:84988416900

SP - 1

EP - 7

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

SN - 0340-1855

ER -