Abstract
Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.
| Original language | English |
|---|---|
| Pages (from-to) | 282-288 |
| Number of pages | 7 |
| Journal | Lupus |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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Keywords
- length
- systemic lupus erythematosus
- Telomere
ASJC Scopus subject areas
- Rheumatology
Cite this
Association between shortened telomere length and systemic lupus erythematosus : A meta-analysis. / Lee, Young Ho; Jung, J. H.; Seo, Y. H.; Kim, J. H.; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Lupus, Vol. 26, No. 3, 01.01.2017, p. 282-288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between shortened telomere length and systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Jung, J. H.
AU - Seo, Y. H.
AU - Kim, J. H.
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.
AB - Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.
KW - length
KW - systemic lupus erythematosus
KW - Telomere
UR - http://www.scopus.com/inward/record.url?scp=85011584212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011584212&partnerID=8YFLogxK
U2 - 10.1177/0961203316662721
DO - 10.1177/0961203316662721
M3 - Article
VL - 26
SP - 282
EP - 288
JO - Lupus
JF - Lupus
SN - 0961-2033
IS - 3
ER -