Association between shortened telomere length and systemic lupus erythematosus

A meta-analysis

Young Ho Lee, J. H. Jung, Y. H. Seo, J. H. Kim, Sungjae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalLupus
Volume26
Issue number3
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Telomere Shortening
Systemic Lupus Erythematosus
Meta-Analysis
Telomere
Confidence Intervals
Control Groups
Blood Cells
Leukocytes
Databases

Keywords

  • length
  • systemic lupus erythematosus
  • Telomere

ASJC Scopus subject areas

  • Rheumatology

Cite this

Association between shortened telomere length and systemic lupus erythematosus : A meta-analysis. / Lee, Young Ho; Jung, J. H.; Seo, Y. H.; Kim, J. H.; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.

In: Lupus, Vol. 26, No. 3, 01.01.2017, p. 282-288.

Research output: Contribution to journalArticle

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abstract = "Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95{\%} confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95{\%} CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95{\%} CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95{\%} CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95{\%} CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95{\%} CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95{\%} CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.",
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AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

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N2 - Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.

AB - Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = -'0.835, 95% confidence interval (CI) = -'1.291 to -'0.380, p = 3.3 × 10-'4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = -'0.455, 95% CI = -'0.763 to -'0.147, p = 0.004; SMD = -'0.887, 95% CI = -'1.261 to -'0.513, p = 3.4 × 10-'4; SMD = -'0.535, 95% CI = -'0.923 to -'0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = -'0.361, 95% CI = -'0.553 to -'0.169, p = 2.3 × 10-'4; SMD = -'1.546, 95% CI = -'2.583 to -'0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = -'0.699, 95% CI = -'1.511 to -'0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.

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