Association between Small Decrease in Serum Sodium Concentration within the Normal Range and All-Cause and Cardiovascular Mortality in Elderly Adults over 5 Years

Shin Young Ahn, Yoon S. Park, Seong W. Lee, Seon H. Baek, Sejoong Kim, Ki Y. Na, Ki W. Kim, Dong Wan Chae, Ho J. Chin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives To determine the importance of a decrease in serum sodium concentration within the normal range in elderly adults. Design Prospective cohort. Setting The Korean Longitudinal Study on Health and Aging. Participants Randomly selected, community-based elderly population with a corrected serum sodium level between 135.0 and 145.0 mEq/L (N = 949). Measurements Survival status was determined during 63.3 ± 16.6 months of follow-up. Results Participants were divided into corrected sodium groups as follows: 73 (7.7%) in Group 1 (sodium 135.0-138.0 mEq/L), 635 (66.9%) in Group 2 (sodium 138.1-142.0 mEq/L), and 241 (25.4%) in Group 3 (sodium 142.1.0-145.0 mEq/L). There were 34 (46.6%) deaths in Group 1, 124 (19.5%) in Group 2, and 52 (21.6%) in Group 3 (P <.001). In a Cox proportional hazards analysis, a 2-mEq/L higher sodium level reduced the risk of death by 14.9% (95% confidence interval (CI) = 0.1-27.4%, P =.048). Group 1 had risk of mortality that was 2.7 times as high as that of Group 2 (95% CI = 1.76-4.11, P <.001). Participants with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level greater than 138.0 mEq/L had a better survival rate than those with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level of 138.0 mEq/L or less. Conclusion A slightly lower serum sodium concentration within the normal range was a major risk factor for mortality in elderly adults. Sodium level corrected according to serum glucose concentration was a more meaningful risk factor than measured sodium level.

Original languageEnglish
Pages (from-to)510-517
Number of pages8
JournalJournal of the American Geriatrics Society
Volume64
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1
Externally publishedYes

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Reference Values
Sodium
Mortality
Serum
Confidence Intervals
Longitudinal Studies
Survival Rate
Glucose

Keywords

  • elderly population
  • mortality
  • sodium

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Association between Small Decrease in Serum Sodium Concentration within the Normal Range and All-Cause and Cardiovascular Mortality in Elderly Adults over 5 Years. / Ahn, Shin Young; Park, Yoon S.; Lee, Seong W.; Baek, Seon H.; Kim, Sejoong; Na, Ki Y.; Kim, Ki W.; Chae, Dong Wan; Chin, Ho J.

In: Journal of the American Geriatrics Society, Vol. 64, No. 3, 01.03.2016, p. 510-517.

Research output: Contribution to journalArticle

Ahn, Shin Young ; Park, Yoon S. ; Lee, Seong W. ; Baek, Seon H. ; Kim, Sejoong ; Na, Ki Y. ; Kim, Ki W. ; Chae, Dong Wan ; Chin, Ho J. / Association between Small Decrease in Serum Sodium Concentration within the Normal Range and All-Cause and Cardiovascular Mortality in Elderly Adults over 5 Years. In: Journal of the American Geriatrics Society. 2016 ; Vol. 64, No. 3. pp. 510-517.
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abstract = "Objectives To determine the importance of a decrease in serum sodium concentration within the normal range in elderly adults. Design Prospective cohort. Setting The Korean Longitudinal Study on Health and Aging. Participants Randomly selected, community-based elderly population with a corrected serum sodium level between 135.0 and 145.0 mEq/L (N = 949). Measurements Survival status was determined during 63.3 ± 16.6 months of follow-up. Results Participants were divided into corrected sodium groups as follows: 73 (7.7{\%}) in Group 1 (sodium 135.0-138.0 mEq/L), 635 (66.9{\%}) in Group 2 (sodium 138.1-142.0 mEq/L), and 241 (25.4{\%}) in Group 3 (sodium 142.1.0-145.0 mEq/L). There were 34 (46.6{\%}) deaths in Group 1, 124 (19.5{\%}) in Group 2, and 52 (21.6{\%}) in Group 3 (P <.001). In a Cox proportional hazards analysis, a 2-mEq/L higher sodium level reduced the risk of death by 14.9{\%} (95{\%} confidence interval (CI) = 0.1-27.4{\%}, P =.048). Group 1 had risk of mortality that was 2.7 times as high as that of Group 2 (95{\%} CI = 1.76-4.11, P <.001). Participants with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level greater than 138.0 mEq/L had a better survival rate than those with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level of 138.0 mEq/L or less. Conclusion A slightly lower serum sodium concentration within the normal range was a major risk factor for mortality in elderly adults. Sodium level corrected according to serum glucose concentration was a more meaningful risk factor than measured sodium level.",
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AU - Park, Yoon S.

AU - Lee, Seong W.

AU - Baek, Seon H.

AU - Kim, Sejoong

AU - Na, Ki Y.

AU - Kim, Ki W.

AU - Chae, Dong Wan

AU - Chin, Ho J.

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N2 - Objectives To determine the importance of a decrease in serum sodium concentration within the normal range in elderly adults. Design Prospective cohort. Setting The Korean Longitudinal Study on Health and Aging. Participants Randomly selected, community-based elderly population with a corrected serum sodium level between 135.0 and 145.0 mEq/L (N = 949). Measurements Survival status was determined during 63.3 ± 16.6 months of follow-up. Results Participants were divided into corrected sodium groups as follows: 73 (7.7%) in Group 1 (sodium 135.0-138.0 mEq/L), 635 (66.9%) in Group 2 (sodium 138.1-142.0 mEq/L), and 241 (25.4%) in Group 3 (sodium 142.1.0-145.0 mEq/L). There were 34 (46.6%) deaths in Group 1, 124 (19.5%) in Group 2, and 52 (21.6%) in Group 3 (P <.001). In a Cox proportional hazards analysis, a 2-mEq/L higher sodium level reduced the risk of death by 14.9% (95% confidence interval (CI) = 0.1-27.4%, P =.048). Group 1 had risk of mortality that was 2.7 times as high as that of Group 2 (95% CI = 1.76-4.11, P <.001). Participants with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level greater than 138.0 mEq/L had a better survival rate than those with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level of 138.0 mEq/L or less. Conclusion A slightly lower serum sodium concentration within the normal range was a major risk factor for mortality in elderly adults. Sodium level corrected according to serum glucose concentration was a more meaningful risk factor than measured sodium level.

AB - Objectives To determine the importance of a decrease in serum sodium concentration within the normal range in elderly adults. Design Prospective cohort. Setting The Korean Longitudinal Study on Health and Aging. Participants Randomly selected, community-based elderly population with a corrected serum sodium level between 135.0 and 145.0 mEq/L (N = 949). Measurements Survival status was determined during 63.3 ± 16.6 months of follow-up. Results Participants were divided into corrected sodium groups as follows: 73 (7.7%) in Group 1 (sodium 135.0-138.0 mEq/L), 635 (66.9%) in Group 2 (sodium 138.1-142.0 mEq/L), and 241 (25.4%) in Group 3 (sodium 142.1.0-145.0 mEq/L). There were 34 (46.6%) deaths in Group 1, 124 (19.5%) in Group 2, and 52 (21.6%) in Group 3 (P <.001). In a Cox proportional hazards analysis, a 2-mEq/L higher sodium level reduced the risk of death by 14.9% (95% confidence interval (CI) = 0.1-27.4%, P =.048). Group 1 had risk of mortality that was 2.7 times as high as that of Group 2 (95% CI = 1.76-4.11, P <.001). Participants with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level greater than 138.0 mEq/L had a better survival rate than those with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level of 138.0 mEq/L or less. Conclusion A slightly lower serum sodium concentration within the normal range was a major risk factor for mortality in elderly adults. Sodium level corrected according to serum glucose concentration was a more meaningful risk factor than measured sodium level.

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