Association between snoring and leukocyte telomere length

Chol Shin, Chang Ho Yun, Dae Wui Yoon, Inkyung Baik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objectives: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. Methods: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) <15 determined in the PSG study were included in the study. Results: We observed that the percentage of time spent snoring during sleep (% time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and logtransformed LTL, coefficient estimates (P value) were -0.076 (<0.05) for the second tertile and -0.084 (<0.01) for the third tertile compared with the bottom tertile. When LTL was compared according to snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 = AHI <15) had shorter LTL than nonsnorers. Conclusions: Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.

Original languageEnglish
Pages (from-to)767-772
Number of pages6
JournalSleep
Volume39
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Snoring
Telomere
Polysomnography
Leukocytes
Apnea
Sleep Apnea Syndromes
Population
Linear Models
Sleep
Epidemiology
Cross-Sectional Studies
Genome
Interviews

Keywords

  • Leukocyte telomere length
  • Polysomnography
  • Population-based study
  • Snoring

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Association between snoring and leukocyte telomere length. / Shin, Chol; Yun, Chang Ho; Yoon, Dae Wui; Baik, Inkyung.

In: Sleep, Vol. 39, No. 4, 01.04.2016, p. 767-772.

Research output: Contribution to journalArticle

Shin, C, Yun, CH, Yoon, DW & Baik, I 2016, 'Association between snoring and leukocyte telomere length', Sleep, vol. 39, no. 4, pp. 767-772. https://doi.org/10.5665/sleep.5624
Shin, Chol ; Yun, Chang Ho ; Yoon, Dae Wui ; Baik, Inkyung. / Association between snoring and leukocyte telomere length. In: Sleep. 2016 ; Vol. 39, No. 4. pp. 767-772.
@article{51eba3dc1d6649299c640de7090116c9,
title = "Association between snoring and leukocyte telomere length",
abstract = "Study Objectives: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. Methods: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) <15 determined in the PSG study were included in the study. Results: We observed that the percentage of time spent snoring during sleep ({\%} time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and logtransformed LTL, coefficient estimates (P value) were -0.076 (<0.05) for the second tertile and -0.084 (<0.01) for the third tertile compared with the bottom tertile. When LTL was compared according to snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 = AHI <15) had shorter LTL than nonsnorers. Conclusions: Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.",
keywords = "Leukocyte telomere length, Polysomnography, Population-based study, Snoring",
author = "Chol Shin and Yun, {Chang Ho} and Yoon, {Dae Wui} and Inkyung Baik",
year = "2016",
month = "4",
day = "1",
doi = "10.5665/sleep.5624",
language = "English",
volume = "39",
pages = "767--772",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "4",

}

TY - JOUR

T1 - Association between snoring and leukocyte telomere length

AU - Shin, Chol

AU - Yun, Chang Ho

AU - Yoon, Dae Wui

AU - Baik, Inkyung

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Study Objectives: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. Methods: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) <15 determined in the PSG study were included in the study. Results: We observed that the percentage of time spent snoring during sleep (% time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and logtransformed LTL, coefficient estimates (P value) were -0.076 (<0.05) for the second tertile and -0.084 (<0.01) for the third tertile compared with the bottom tertile. When LTL was compared according to snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 = AHI <15) had shorter LTL than nonsnorers. Conclusions: Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.

AB - Study Objectives: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. Methods: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) <15 determined in the PSG study were included in the study. Results: We observed that the percentage of time spent snoring during sleep (% time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and logtransformed LTL, coefficient estimates (P value) were -0.076 (<0.05) for the second tertile and -0.084 (<0.01) for the third tertile compared with the bottom tertile. When LTL was compared according to snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 = AHI <15) had shorter LTL than nonsnorers. Conclusions: Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.

KW - Leukocyte telomere length

KW - Polysomnography

KW - Population-based study

KW - Snoring

UR - http://www.scopus.com/inward/record.url?scp=84962425222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962425222&partnerID=8YFLogxK

U2 - 10.5665/sleep.5624

DO - 10.5665/sleep.5624

M3 - Article

C2 - 26715224

AN - SCOPUS:84962425222

VL - 39

SP - 767

EP - 772

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 4

ER -