Association between sRAGE, esRAGE levels and vascular inflammation

Analysis with 18F-fluorodeoxyglucose positron emission tomography

Sae Jeong Yang, Sungeun Kim, Soon Young Hwang, Tae Nyun Kim, Hae Yoon Choi, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation. Methods: We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular 18F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated. Results: Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR. Conclusions: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalAtherosclerosis
Volume220
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Blood Vessels
Inflammation
Carotid Intima-Media Thickness
Type 2 Diabetes Mellitus
Healthy Volunteers
Carotid Arteries
Linear Models
Cardiovascular Diseases
Regression Analysis
Advanced Glycosylation End Product-Specific Receptor
human esRAGE protein
Ligands

Keywords

  • Atherosclerosis
  • Inflammation
  • Positron emission tomography
  • RAGE
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association between sRAGE, esRAGE levels and vascular inflammation : Analysis with 18F-fluorodeoxyglucose positron emission tomography. / Yang, Sae Jeong; Kim, Sungeun; Hwang, Soon Young; Kim, Tae Nyun; Choi, Hae Yoon; Yoo, Hye-Jin; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Atherosclerosis, Vol. 220, No. 2, 01.02.2012, p. 402-406.

Research output: Contribution to journalArticle

@article{1af129947f2b43e3a47bc2b1fdc35231,
title = "Association between sRAGE, esRAGE levels and vascular inflammation: Analysis with 18F-fluorodeoxyglucose positron emission tomography",
abstract = "Background: The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation. Methods: We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular 18F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated. Results: Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR. Conclusions: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation.",
keywords = "Atherosclerosis, Inflammation, Positron emission tomography, RAGE, Type 2 diabetes",
author = "Yang, {Sae Jeong} and Sungeun Kim and Hwang, {Soon Young} and Kim, {Tae Nyun} and Choi, {Hae Yoon} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Sei-Hyun Baik and Choi, {Dong Seop} and Choi, {Kyung Mook}",
year = "2012",
month = "2",
day = "1",
doi = "10.1016/j.atherosclerosis.2011.11.008",
language = "English",
volume = "220",
pages = "402--406",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Association between sRAGE, esRAGE levels and vascular inflammation

T2 - Analysis with 18F-fluorodeoxyglucose positron emission tomography

AU - Yang, Sae Jeong

AU - Kim, Sungeun

AU - Hwang, Soon Young

AU - Kim, Tae Nyun

AU - Choi, Hae Yoon

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Background: The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation. Methods: We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular 18F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated. Results: Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR. Conclusions: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation.

AB - Background: The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation. Methods: We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular 18F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated. Results: Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR. Conclusions: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation.

KW - Atherosclerosis

KW - Inflammation

KW - Positron emission tomography

KW - RAGE

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84855951223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855951223&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2011.11.008

DO - 10.1016/j.atherosclerosis.2011.11.008

M3 - Article

VL - 220

SP - 402

EP - 406

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -