Association between statin treatment and new-onset diabetes mellitus: a population based case-control study

Dong Won Kim, Do-Hoon Kim, Joo Hyun Park, Moonyoung Choi, Shinhye Kim, Hyonchong Kim, Da eun Seul, Soo Gyeong Park, Jin Hyung Jung, Kyungdo Han, Yong Gyu Park

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Abstract

Background: Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods: We used the South Korean National Health Insurance Service National Sample Cohort database for this nationwide case-control study. Of the 1 million participants, 6417 participants with NODM in 2012-2013 and 32,085 controls without diabetes (1:5 propensity score matched with age, sex, index year, and year of diabetes diagnosis) were included. In these patients, we examined the statin prescription record for 3 years preceding the outcome. We used conditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results: After adjustment of covariates, there were no significant differences in the risk of NODM when analyzed according to cumulative use days. The risk of NODM was increased only in the short-term and recent user group (OR 1.48, 95% CI 1.21 to 1.82) whose cumulative prescription days are less than 6 months and whose last prescription is within 6 months of diagnosis. Conclusions: The risk of NODM was not associated with an increase in the cumulative duration of statin use or with non-recent use. Only recent short-term use of statin was associated with an increased risk of NODM. Diabetes screening are warranted during initial statin therapy.

Original languageEnglish
Article number30
JournalDiabetology and Metabolic Syndrome
Volume11
Issue number1
DOIs
Publication statusPublished - 2019 Apr 22

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Keywords

  • Case-control study
  • Diabetes mellitus
  • New-onset diabetes
  • Population-based study
  • Statins

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Kim, D. W., Kim, D-H., Park, J. H., Choi, M., Kim, S., Kim, H., Seul, D. E., Park, S. G., Jung, J. H., Han, K., & Park, Y. G. (2019). Association between statin treatment and new-onset diabetes mellitus: a population based case-control study. Diabetology and Metabolic Syndrome, 11(1), [30]. https://doi.org/10.1186/s13098-019-0427-9