Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder

Seung Hwan Lee, Kang Joon Lee, Heon Jeong Lee, Byung Joo Ham, Seung Ho Ryu, Min Soo Lee

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The purpose of the present study was to determine if a 5-HT6 receptor polymorphism is associated with antidepressant treatment response in major depressive disorder (MDD). Ninety-one patients with MDD, compared with 127 normal control subjects, were evaluated after an 8-week treatment period. An association analysis revealed no differences in genotype and allele distribution between patients with MDD and normal control subjects. However, there were significant differences in the treatment response in some Hamilton Depression Rating Scale (HAM-D) scores (sleep, activity, somatic anxiety, and total) between genotypes. Moreover, the heterozygote group (CT genotype) had significantly better treatment response than the homozygote group (CC+ TT genotypes), especially in the somatic-anxiety subcategory and the total score of HAM-D. These findings imply that a 5-HT6 receptor polymorphism (C267T) is associated with treatment response in MDD.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalPsychiatry and Clinical Neurosciences
Volume59
Issue number2
DOIs
Publication statusPublished - 2005 Apr

Keywords

  • Heterosis
  • Major depressive disorder
  • Polymorphism
  • Serotonin receptor 6 gene
  • Treatment response

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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