Association between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus: A meta-analysis

Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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    8 Citations (Scopus)

    Abstract

    Objective: The aim of this study was to determine whether the insertion (I) /deletion (D) polymorphism within intron 16 of angiotensin-converting enzyme (ACE) confers susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). Methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and SLE and LN. Results: A total of 1907 patients with SLE and 1842 controls in 18 comparative studies were included in this metaanalysis. The analysis showed a significant association between SLE and the DD genotype (recessive effect) of the ACE polymorphism (odds ratio [OR] 1.383, 95% confidence interval [CI] 1.065-1.797, p = 0.015). Stratification by ethnicity indicated a marginal association between the DD genotype and SLE in Europeans (OR 1.210, 95% CI 0.964-1.519, p = 0.099; I2 = 0%). Meta-analysis also revealed a trend toward to an association between SLE and the ACE polymorphism using the allelic or additive models in Europeans. Furthermore, meta-analysis of the DD+ID genotype showed a significant association with LN (OR 0.582, 95% CI 0.425-0.797, p = 0.001; I2 = 0%). Conclusion: This meta-analysis demonstrates a strong association between DD genotype and SLE in overall study and a marginal association between SLE and the ACE D/I polymorphism in Europeans, and suggests that this polymorphism might confer susceptibility to LN.

    Original languageEnglish
    Pages (from-to)248-254
    Number of pages7
    JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - 2013 Sep

    Keywords

    • Systemic lupus erythematosus
    • angiotensin-converting enzyme
    • lupus nephritis
    • meta-analysis
    • polymorphism

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology

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