TY - JOUR
T1 - Association between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Choi, Sung Jae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2013/9
Y1 - 2013/9
N2 - Objective: The aim of this study was to determine whether the insertion (I) /deletion (D) polymorphism within intron 16 of angiotensin-converting enzyme (ACE) confers susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). Methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and SLE and LN. Results: A total of 1907 patients with SLE and 1842 controls in 18 comparative studies were included in this metaanalysis. The analysis showed a significant association between SLE and the DD genotype (recessive effect) of the ACE polymorphism (odds ratio [OR] 1.383, 95% confidence interval [CI] 1.065-1.797, p = 0.015). Stratification by ethnicity indicated a marginal association between the DD genotype and SLE in Europeans (OR 1.210, 95% CI 0.964-1.519, p = 0.099; I2 = 0%). Meta-analysis also revealed a trend toward to an association between SLE and the ACE polymorphism using the allelic or additive models in Europeans. Furthermore, meta-analysis of the DD+ID genotype showed a significant association with LN (OR 0.582, 95% CI 0.425-0.797, p = 0.001; I2 = 0%). Conclusion: This meta-analysis demonstrates a strong association between DD genotype and SLE in overall study and a marginal association between SLE and the ACE D/I polymorphism in Europeans, and suggests that this polymorphism might confer susceptibility to LN.
AB - Objective: The aim of this study was to determine whether the insertion (I) /deletion (D) polymorphism within intron 16 of angiotensin-converting enzyme (ACE) confers susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). Methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and SLE and LN. Results: A total of 1907 patients with SLE and 1842 controls in 18 comparative studies were included in this metaanalysis. The analysis showed a significant association between SLE and the DD genotype (recessive effect) of the ACE polymorphism (odds ratio [OR] 1.383, 95% confidence interval [CI] 1.065-1.797, p = 0.015). Stratification by ethnicity indicated a marginal association between the DD genotype and SLE in Europeans (OR 1.210, 95% CI 0.964-1.519, p = 0.099; I2 = 0%). Meta-analysis also revealed a trend toward to an association between SLE and the ACE polymorphism using the allelic or additive models in Europeans. Furthermore, meta-analysis of the DD+ID genotype showed a significant association with LN (OR 0.582, 95% CI 0.425-0.797, p = 0.001; I2 = 0%). Conclusion: This meta-analysis demonstrates a strong association between DD genotype and SLE in overall study and a marginal association between SLE and the ACE D/I polymorphism in Europeans, and suggests that this polymorphism might confer susceptibility to LN.
KW - Systemic lupus erythematosus
KW - angiotensin-converting enzyme
KW - lupus nephritis
KW - meta-analysis
KW - polymorphism
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U2 - 10.1177/1470320312459979
DO - 10.1177/1470320312459979
M3 - Article
C2 - 23047029
AN - SCOPUS:84882957642
VL - 14
SP - 248
EP - 254
JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
JF - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
SN - 1470-3203
IS - 3
ER -