Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia

Byung-Joo Ham, Min-Soo Lee, Young-Mee Lee, Meyoung-Kon Kim, Myoung Jin Choi, Kang Seob Oh, Yong Jung Han, Kyoon Lyoo In, Ihn Geun Choi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

It has been suggested that the characteristics of alexithymia result from deficits in frontal lobe functioning, and the prefrontal cortex is particularly dependent on the catechol O-methyltransferase (COMT) pathway. We investigated the relationship between COMT Val108/158Met, serotonin transporter coding sequence (5-HT transporter gene-linked polymorphic region; 5-HTTLPR) polymorphisms, and alexithymia. The study sample comprised 109 students at the Korea University. All participants were tested using the 20-item Toronto Alexithymia Scale (TAS-20). They were genotyped for COMT Val108/158Met and 5-HTTLPR polymorphisms. Genotyping was analyzed using polymerase chain reaction. Subjects with Val/Val genotype had significantly higher TAS-20 scores than those with Met/Met or Met/Val genotypes. However, there was no significant relationship between the 5-HTTLPR genotype and TAS-20 scores. This indicates a possible association between the COMT Val108/158Met gene polymorphism and alexithymia.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalNeuropsychobiology
Volume52
Issue number3
DOIs
Publication statusPublished - 2005 Sep 1

Fingerprint

Catechol O-Methyltransferase
Affective Symptoms
Genotype
Serotonin Plasma Membrane Transport Proteins
Frontal Lobe
Korea
Prefrontal Cortex
Genes
Serotonin
Students
Polymerase Chain Reaction

Keywords

  • 5-HTTLPR polymorphism
  • Alexithymia
  • Catechol o-methyltransferase

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia. / Ham, Byung-Joo; Lee, Min-Soo; Lee, Young-Mee; Kim, Meyoung-Kon; Choi, Myoung Jin; Oh, Kang Seob; Han, Yong Jung; In, Kyoon Lyoo; Choi, Ihn Geun.

In: Neuropsychobiology, Vol. 52, No. 3, 01.09.2005, p. 151-154.

Research output: Contribution to journalArticle

Ham, Byung-Joo ; Lee, Min-Soo ; Lee, Young-Mee ; Kim, Meyoung-Kon ; Choi, Myoung Jin ; Oh, Kang Seob ; Han, Yong Jung ; In, Kyoon Lyoo ; Choi, Ihn Geun. / Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia. In: Neuropsychobiology. 2005 ; Vol. 52, No. 3. pp. 151-154.
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