Association between the CTLA-4 +49 A/G polymorphism and susceptibility to rheumatoid arthritis: A meta-analysis

Young Ho Lee, Sang Cheol Bae, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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    20 Citations (Scopus)

    Abstract

    The aim of this study was to explore whether the cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G polymorphism confers susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between CTLA-4 +49 A/G polymorphism and RA using; 1) allele contrast, 2) the recessive model, 3) the dominant model, and 4) an additive model. A total of 19 studies, 5,752 RA patients and 5,508 controls, encompassing 9 Caucasian, 8 Asian, 1 Mexican, and 1 Tunisian population were included in this meta-analysis. Ethnicity-specific meta-analysis was performed on Caucasian and Asian populations. Metaanalysis of the CTLA-4+49 A/G polymorphism revealed an association between RA and the CTLA-4 +49 G allele in all 11,260 study subjects (odds ratio (OR) 1.118, 95% confidence interval (CI) 1.033-1.210, P = 0.005). Stratification by ethnicity showed an association between the CTLA-4 +49 G allele and RA in Asians (OR 1.164, 95% CI 1.056-1.283, P = 0.002), but no evidence of an association in Caucasians (OR 1.085, 95% CI 0.973-1.209, P = 0.431). Furthermore, associations were found between RA and the CTLA-4 +49 A/G polymorphism in Asians using the dominant and additive models, but not using the recessive model. On the other hand, no association was found between RA and the CTLA-4 +49 A/G polymorphism using the recessive, dominant, or additive models in Caucasians. This meta-analysis demonstrates that the CTLA-4 +49 A/G polymorphism confers susceptibility to RA in Asians, but not in Caucasians.

    Original languageEnglish
    Pages (from-to)5599-5605
    Number of pages7
    JournalMolecular biology reports
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - 2012 May

    Keywords

    • CTLA-4
    • Meta-analysis
    • Polymorphism
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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