TY - JOUR
T1 - Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Song, Gwan Gyu
N1 - Funding Information:
This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare , Republic of Korea ( HI13C2124 ).
Publisher Copyright:
© 2015 American Society for Histocompatibility and Immunogenetics.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Objective: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). Methods: We performed a meta-analysis on the association between the four gene polymorphisms and RA. Results: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR. =. 1.057, 95% CI. =. 0.782-1.429, p=. 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR. =. 1.294, 95% CI. =. 1.063-1.576, p=. 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR. =. 1.363, 95% CI. =. 1.126-1.651, p=. 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR. =. 1.366, 95% CI. =. 1.093-1.707, p=. 0.006) and in Asians (OR. =. 1.402, 95% CI. =. 1.059-1.855, p=. 0.014). Conclusions: Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
AB - Objective: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). Methods: We performed a meta-analysis on the association between the four gene polymorphisms and RA. Results: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR. =. 1.057, 95% CI. =. 0.782-1.429, p=. 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR. =. 1.294, 95% CI. =. 1.063-1.576, p=. 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR. =. 1.363, 95% CI. =. 1.126-1.651, p=. 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR. =. 1.366, 95% CI. =. 1.093-1.707, p=. 0.006) and in Asians (OR. =. 1.402, 95% CI. =. 1.059-1.855, p=. 0.014). Conclusions: Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
KW - CD226
KW - CTLA-4
KW - FAS
KW - Polymorphism
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=84924043054&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2015.01.023
DO - 10.1016/j.humimm.2015.01.023
M3 - Article
C2 - 25645050
AN - SCOPUS:84924043054
SN - 0198-8859
VL - 76
SP - 83
EP - 89
JO - Human Immunology
JF - Human Immunology
IS - 2-3
ER -