Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Young Ho Lee, Sang Cheol Bae, Gwan Gyu Song

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). Methods: We performed a meta-analysis on the association between the four gene polymorphisms and RA. Results: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR. =. 1.057, 95% CI. =. 0.782-1.429, p=. 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR. =. 1.294, 95% CI. =. 1.063-1.576, p=. 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR. =. 1.363, 95% CI. =. 1.126-1.651, p=. 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR. =. 1.366, 95% CI. =. 1.093-1.707, p=. 0.006) and in Asians (OR. =. 1.402, 95% CI. =. 1.059-1.855, p=. 0.014). Conclusions: Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalHuman Immunology
Volume76
Issue number2-3
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • CD226
  • CTLA-4
  • FAS
  • Polymorphism
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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