The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.
- Rheumatoid arthritis
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