Association between the functional MHC2TA −168 A/G polymorphism and susceptibility to rheumatoid arthritis

A meta-analysis

Young Ho Lee, Sang Cheol Bae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.

Original languageEnglish
Pages (from-to)901-909
Number of pages9
JournalClinical Rheumatology
Volume35
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Rheumatoid Factor
Meta-Analysis
Rheumatoid Arthritis
Alleles
Trans-Activators
Major Histocompatibility Complex
Gene Frequency
Population

Keywords

  • Meta-analysis
  • MHC2TA
  • Polymorphism
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Association between the functional MHC2TA −168 A/G polymorphism and susceptibility to rheumatoid arthritis : A meta-analysis. / Lee, Young Ho; Bae, Sang Cheol.

In: Clinical Rheumatology, Vol. 35, No. 4, 01.04.2016, p. 901-909.

Research output: Contribution to journalArticle

@article{a6d0654f689946d8a2721b2ee04f1a51,
title = "Association between the functional MHC2TA −168 A/G polymorphism and susceptibility to rheumatoid arthritis: A meta-analysis",
abstract = "The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 {\%} CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 {\%} CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 {\%} CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 {\%} CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.",
keywords = "Meta-analysis, MHC2TA, Polymorphism, Rheumatoid arthritis",
author = "Lee, {Young Ho} and Bae, {Sang Cheol}",
year = "2016",
month = "4",
day = "1",
doi = "10.1007/s10067-015-3089-5",
language = "English",
volume = "35",
pages = "901--909",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer London",
number = "4",

}

TY - JOUR

T1 - Association between the functional MHC2TA −168 A/G polymorphism and susceptibility to rheumatoid arthritis

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Bae, Sang Cheol

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.

AB - The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.

KW - Meta-analysis

KW - MHC2TA

KW - Polymorphism

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=84944549812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944549812&partnerID=8YFLogxK

U2 - 10.1007/s10067-015-3089-5

DO - 10.1007/s10067-015-3089-5

M3 - Article

VL - 35

SP - 901

EP - 909

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 4

ER -