TY - JOUR
T1 - Association between the functional MHC2TA −168 A/G polymorphism and susceptibility to rheumatoid arthritis
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
N1 - Funding Information:
This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).
Publisher Copyright:
© International League of Associations for Rheumatology (ILAR) 2015.
PY - 2016/4
Y1 - 2016/4
N2 - The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.
AB - The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) −168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA −168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA −168 G allele in the study subjects (OR=1.046, 95 % CI= 0.987–1.108, p=0.130) or Caucasians (OR=1.027, 95 % CI= 0.986–1.070, p=0.193). However, the country-specific metaanalysis revealed an association between the MHC2TA −168 G allele and RA in the Swedish population (OR=1.131, 95 % CI=1.023–1.250, p=0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR=0.783, 95 % CI=0.628– 0.975, p=0.029) than in RF-negative patients. This metaanalysis demonstrated that the MHC2TA −168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.
KW - MHC2TA
KW - Meta-analysis
KW - Polymorphism
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=84944549812&partnerID=8YFLogxK
U2 - 10.1007/s10067-015-3089-5
DO - 10.1007/s10067-015-3089-5
M3 - Article
C2 - 26439834
AN - SCOPUS:84944549812
SN - 0770-3198
VL - 35
SP - 901
EP - 909
JO - Clinical Rheumatology
JF - Clinical Rheumatology
IS - 4
ER -