Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea

C. I. Joung, J. B. Jun, W. T. Chung, Gwan Gyu Song, J. Y. Choe, H. K. Chang, D. H. Yoo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. Methods: Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology (ACR) classification criteria for SSc were enrolled. The controls were 144 healthy, disease-free Koreans. HLA-DRB1 genotypes were assessed by the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. Results: The HLA-DRB1*15 allele was increased in anti-topoisomerase I autoantibody (anti-topo I)-positive SSc patients [p=0.003, p corrected (pcorr)=0.039, odds ratio (OR)=3.43, 95% confidence interval (CI) 1.45-8.13] compared with controls. The DRB1*11 allele was also observed more frequently in anti-topo I-positive SSc than in controls (13.3% vs. 4.2%) but not statistically significant (p=0.053, p corr=0.689). In patients with SSc, the DRB1*04 allele was associated with subcutaneous calcinosis (p=0.048, OR=4.56, 95% CI 1.07-19.37). Patients with overlap syndrome showed a negative association with the DRB1*04 allele (p=0.036, OR=0.26, 95% CI 0.08-0.91). Conclusion: The HLA-DRB1*15 allele was associated with the development of anti-topo I-positive SSc in Koreans. In addition, the DRB1*04 allele was associated with certain clinical features in SSc patients.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalScandinavian Journal of Rheumatology
Volume35
Issue number1
DOIs
Publication statusPublished - 2006 Feb 1

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HLA-DRB1 Chains
Systemic Scleroderma
Korea
Alleles
Type I DNA Topoisomerase
Genes
Autoantibodies
Odds Ratio
Confidence Intervals
Calcinosis
Oligonucleotide Probes
HLA-DR Antigens
Genotype
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea. / Joung, C. I.; Jun, J. B.; Chung, W. T.; Song, Gwan Gyu; Choe, J. Y.; Chang, H. K.; Yoo, D. H.

In: Scandinavian Journal of Rheumatology, Vol. 35, No. 1, 01.02.2006, p. 39-43.

Research output: Contribution to journalArticle

Joung, C. I. ; Jun, J. B. ; Chung, W. T. ; Song, Gwan Gyu ; Choe, J. Y. ; Chang, H. K. ; Yoo, D. H. / Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea. In: Scandinavian Journal of Rheumatology. 2006 ; Vol. 35, No. 1. pp. 39-43.
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abstract = "Objective: To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. Methods: Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology (ACR) classification criteria for SSc were enrolled. The controls were 144 healthy, disease-free Koreans. HLA-DRB1 genotypes were assessed by the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. Results: The HLA-DRB1*15 allele was increased in anti-topoisomerase I autoantibody (anti-topo I)-positive SSc patients [p=0.003, p corrected (pcorr)=0.039, odds ratio (OR)=3.43, 95{\%} confidence interval (CI) 1.45-8.13] compared with controls. The DRB1*11 allele was also observed more frequently in anti-topo I-positive SSc than in controls (13.3{\%} vs. 4.2{\%}) but not statistically significant (p=0.053, p corr=0.689). In patients with SSc, the DRB1*04 allele was associated with subcutaneous calcinosis (p=0.048, OR=4.56, 95{\%} CI 1.07-19.37). Patients with overlap syndrome showed a negative association with the DRB1*04 allele (p=0.036, OR=0.26, 95{\%} CI 0.08-0.91). Conclusion: The HLA-DRB1*15 allele was associated with the development of anti-topo I-positive SSc in Koreans. In addition, the DRB1*04 allele was associated with certain clinical features in SSc patients.",
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AU - Choe, J. Y.

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AU - Yoo, D. H.

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N2 - Objective: To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. Methods: Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology (ACR) classification criteria for SSc were enrolled. The controls were 144 healthy, disease-free Koreans. HLA-DRB1 genotypes were assessed by the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. Results: The HLA-DRB1*15 allele was increased in anti-topoisomerase I autoantibody (anti-topo I)-positive SSc patients [p=0.003, p corrected (pcorr)=0.039, odds ratio (OR)=3.43, 95% confidence interval (CI) 1.45-8.13] compared with controls. The DRB1*11 allele was also observed more frequently in anti-topo I-positive SSc than in controls (13.3% vs. 4.2%) but not statistically significant (p=0.053, p corr=0.689). In patients with SSc, the DRB1*04 allele was associated with subcutaneous calcinosis (p=0.048, OR=4.56, 95% CI 1.07-19.37). Patients with overlap syndrome showed a negative association with the DRB1*04 allele (p=0.036, OR=0.26, 95% CI 0.08-0.91). Conclusion: The HLA-DRB1*15 allele was associated with the development of anti-topo I-positive SSc in Koreans. In addition, the DRB1*04 allele was associated with certain clinical features in SSc patients.

AB - Objective: To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. Methods: Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology (ACR) classification criteria for SSc were enrolled. The controls were 144 healthy, disease-free Koreans. HLA-DRB1 genotypes were assessed by the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. Results: The HLA-DRB1*15 allele was increased in anti-topoisomerase I autoantibody (anti-topo I)-positive SSc patients [p=0.003, p corrected (pcorr)=0.039, odds ratio (OR)=3.43, 95% confidence interval (CI) 1.45-8.13] compared with controls. The DRB1*11 allele was also observed more frequently in anti-topo I-positive SSc than in controls (13.3% vs. 4.2%) but not statistically significant (p=0.053, p corr=0.689). In patients with SSc, the DRB1*04 allele was associated with subcutaneous calcinosis (p=0.048, OR=4.56, 95% CI 1.07-19.37). Patients with overlap syndrome showed a negative association with the DRB1*04 allele (p=0.036, OR=0.26, 95% CI 0.08-0.91). Conclusion: The HLA-DRB1*15 allele was associated with the development of anti-topo I-positive SSc in Koreans. In addition, the DRB1*04 allele was associated with certain clinical features in SSc patients.

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