Association between the il10 rs1800896 polymorphism and tardive dyskinesia in schizophrenia

Kwang Yeon Choi, Jeong Min Choo, Youn Jung Lee, Yujin Lee, Chul Hyun Cho, Seung Hyun Kim, Heon Jeong Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective Interleukin-10 (IL-10) is a major immunoregulatory cytokine and its gene plays a fundamental role in anti-inflammatory and immunosuppressive activity. This study aimed to examine the association between the IL10 gene promoter-1082G/A polymorphism (rs1800896) and tardive dyskinesia (TD) in schizophrenia. Methods Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). TD was diagnosed using the Research Diagnostic Criteria for TD and Abnormal Involuntary Movement Scale (AIMS). Genotyping was per-formed by RT-PCR and high-resolution melting curve analysis. Results The distributions of genotypic frequencies did not differ between patients with and without TD (χ2=4.33, p=0.115). However, allelic frequencies of the two groups were different (χ2=4.45, p=0.035); the A allele frequency was higher in TD. The total AIMS scores of the three genotypes were not different (F=1.33, p=0.266). However, the total AIMS scores of the A allele carrier and the A allele non-carri-er were significantly different (t=5.79, p<0.001). Logistic regression analaysis showed that IL10-1082G/A genotype significantly predicts presence of TD (p=0.045) after adjusting for covariates such as age and treatment duration. Conclusion This finding suggests that the A allele of rs1800896 may be associated with TD development following a low IL-10 function.

Original languageEnglish
Pages (from-to)1031-1036
Number of pages6
JournalPsychiatry Investigation
Volume17
Issue number10
DOIs
Publication statusPublished - 2020 Oct
Externally publishedYes

Keywords

  • Interleukin-10
  • Oxidative stress
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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