Abstract
The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism, rs2004640, confers susceptibility to systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism and 12 studies were included in the meta-analysis. Meta-analysis revealed an association between SLE and the IRF5 rs2004640 T allele in all subjects without inter-study heterogeneity (OR 1.429, 95% CI 1.359-1.503, P < 0.001). The IRF5 rs2004640 T allele was significantly associated with SLE in European and Asians. The Asian population had a much lower prevalence of the T allele (34.4%) than any other population studied. and Europeans had the highest frequency of the IRF5 rs2004640 T allele (51.8%). In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1142 |
| Number of pages | 6 |
| Journal | Rheumatology International |
| Volume | 29 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2009 Aug 1 |
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Keywords
- IRF5
- Meta-analysis
- Polymorphism
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
Cite this
Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus : A meta-analysis. / Lee, Young Ho; Song, Gwan Gyu.
In: Rheumatology International, Vol. 29, No. 10, 01.08.2009, p. 1137-1142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Song, Gwan Gyu
PY - 2009/8/1
Y1 - 2009/8/1
N2 - The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism, rs2004640, confers susceptibility to systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism and 12 studies were included in the meta-analysis. Meta-analysis revealed an association between SLE and the IRF5 rs2004640 T allele in all subjects without inter-study heterogeneity (OR 1.429, 95% CI 1.359-1.503, P < 0.001). The IRF5 rs2004640 T allele was significantly associated with SLE in European and Asians. The Asian population had a much lower prevalence of the T allele (34.4%) than any other population studied. and Europeans had the highest frequency of the IRF5 rs2004640 T allele (51.8%). In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
AB - The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism, rs2004640, confers susceptibility to systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism and 12 studies were included in the meta-analysis. Meta-analysis revealed an association between SLE and the IRF5 rs2004640 T allele in all subjects without inter-study heterogeneity (OR 1.429, 95% CI 1.359-1.503, P < 0.001). The IRF5 rs2004640 T allele was significantly associated with SLE in European and Asians. The Asian population had a much lower prevalence of the T allele (34.4%) than any other population studied. and Europeans had the highest frequency of the IRF5 rs2004640 T allele (51.8%). In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
KW - IRF5
KW - Meta-analysis
KW - Polymorphism
KW - Systemic lupus erythematosus
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U2 - 10.1007/s00296-008-0801-7
DO - 10.1007/s00296-008-0801-7
M3 - Article
C2 - 19043711
AN - SCOPUS:68149137024
VL - 29
SP - 1137
EP - 1142
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 10
ER -