Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: A meta-analysis

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Abstract

Objective: The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). Methods: A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). Results: Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10-6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10-7) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10-8; OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10-8, respectively). Conclusions: This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalHuman Immunology
Volume73
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

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Type 1 Diabetes Mellitus
Meta-Analysis
Alleles
Population

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

@article{795ec26787d84fd5a8380cc5647b9fd8,
title = "Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). Methods: A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). Results: Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4{\%} vs. 30.2{\%}). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95{\%} CI=1.112-1.373, p=7.9×10-6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95{\%} CI=1.169-1.452, p=1.78×10-7) and a marginal association with T1D in Europeans (OR=1.177, 95{\%} CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95{\%} CI=1.144-1.342, p=1.4×10-8; OR=1.156, 95{\%} CI=1.051-1.271, p=0.003; OR=1.461, 95{\%} CI=1.262-1.691, p=3.8×10-8, respectively). Conclusions: This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.",
author = "Song, {Gwan Gyu} and Sungjae Choi and Ji, {Jong Dae} and Lee, {Young Ho}",
year = "2012",
month = "10",
day = "1",
doi = "10.1016/j.humimm.2012.07.341",
language = "English",
volume = "73",
pages = "1055--1059",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "10",

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TY - JOUR

T1 - Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Objective: The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). Methods: A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). Results: Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10-6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10-7) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10-8; OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10-8, respectively). Conclusions: This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.

AB - Objective: The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). Methods: A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). Results: Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10-6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10-7) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10-8; OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10-8, respectively). Conclusions: This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.

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