Association between TNF-α (-308 A/G,-238 A/G,-857 C/T polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease

A meta-analysis

Gwan Gyu Song, Young Ho Seo, Jae Hoon Kim, Sungjae Choi, Jong Dae Ji, Young Ho Lee

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Aim: The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-α-308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 × 10-5), TNF-α-238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-α-857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-α blockers in Caucasians. Conclusion: Individuals carrying the TNF-α-308 G,-238 G, or-857 C common alleles show better responses to TNF-α blockers than those with minor alleles in Caucasians.

Original languageEnglish
Pages (from-to)1427-1437
Number of pages11
JournalPharmacogenomics
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Jan 1

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Spondylarthropathies
Psoriasis
Crohn Disease
Meta-Analysis
Alleles

Keywords

  • psoriasis
  • responsiveness
  • spondyloarthropathy
  • TNF-α inhibitors
  • TNF-α polymorphism

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

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title = "Association between TNF-α (-308 A/G,-238 A/G,-857 C/T polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: A meta-analysis",
abstract = "Aim: The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-α-308 G allele (OR = 2.005; 95{\%} CI: 1.417-2.838; p = 8.6 × 10-5), TNF-α-238 G allele (OR = 2.196; 95{\%} CI: 1161-4.154; p = 0.016), and TNF-α-857 C allele (OR = 1.779; 95{\%} CI: 1.130-2.802; p = 0.013) and response to TNF-α blockers in Caucasians. Conclusion: Individuals carrying the TNF-α-308 G,-238 G, or-857 C common alleles show better responses to TNF-α blockers than those with minor alleles in Caucasians.",
keywords = "psoriasis, responsiveness, spondyloarthropathy, TNF-α inhibitors, TNF-α polymorphism",
author = "Song, {Gwan Gyu} and Seo, {Young Ho} and Kim, {Jae Hoon} and Sungjae Choi and Ji, {Jong Dae} and Lee, {Young Ho}",
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language = "English",
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T1 - Association between TNF-α (-308 A/G,-238 A/G,-857 C/T polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Seo, Young Ho

AU - Kim, Jae Hoon

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Aim: The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-α-308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 × 10-5), TNF-α-238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-α-857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-α blockers in Caucasians. Conclusion: Individuals carrying the TNF-α-308 G,-238 G, or-857 C common alleles show better responses to TNF-α blockers than those with minor alleles in Caucasians.

AB - Aim: The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Methods: We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients. Results: The meta-analysis indicated an association between the TNF-α-308 G allele (OR = 2.005; 95% CI: 1.417-2.838; p = 8.6 × 10-5), TNF-α-238 G allele (OR = 2.196; 95% CI: 1161-4.154; p = 0.016), and TNF-α-857 C allele (OR = 1.779; 95% CI: 1.130-2.802; p = 0.013) and response to TNF-α blockers in Caucasians. Conclusion: Individuals carrying the TNF-α-308 G,-238 G, or-857 C common alleles show better responses to TNF-α blockers than those with minor alleles in Caucasians.

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KW - TNF-α polymorphism

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