Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk

A systematic review and meta-analysis

Jong Pill Yang, Myung Han Hyun, Jeong Min Yoon, Min Jeong Park, Donghyeok Kim, Sungsoo Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Tumor necrosis factor-alpha (TNF-α) has been found to be associated with gastric carcinogenesis, but individually published results have been inconclusive. The aim of this study was to explore the relationship between the TNF-α-308 G/A polymorphism and gastric cancer risk. Methods: MEDLINE, EMBASE and the COCHRANE library databases were searched for relevant articles to identify all available data. The odds ratios (ORs) with 95% confidence intervals (95% CIs) from each study were used to assess the association between the TNF-α-308 G/A polymorphism and gastric cancer risk. Results: This meta-analysis included 30 studies (32 datasets) involving 7009 gastric cancer cases and 12,119 control subjects. Overall, a significant association was found between the TNF-α-308 G/A polymorphism and gastric cancer in AA. +. GA vs. GG (dominant contrast model) (OR. =. 1.20, 95% CI. =. 1.07-1.34, p=. 0.001). With stratification based on ethnicity, the TNF-α-308 G/A polymorphism was correlated with gastric cancer risk in Caucasians, using the dominant contrast model (OR. =. 0.74, 95% CI. =. 0.57-0.96, p=. 0.02), but not in East Asians and other ethnic groups. In the comprehensive subgroup analysis, a significant association was also found in recent articles (published after 2005), population-based high-quality studies, hospital-based high-quality studies, studies using the TaqMan method and non-cardia subgroups. However, the TNF-α-308 G/A polymorphism was not associated with specific histological types of gastric cancer risk. Conclusions: The TNF-α-308 G/A polymorphism may contribute to susceptibility to gastric cancer in Caucasians, especially for non-cardia gastric cancer, as most strongly demonstrated in high-quality studies and in studies using the TaqMan genotyping method. Furthermore, we recommend the TaqMan method as the preferred genotyping method in DNA polymorphism studies.

Original languageEnglish
Pages (from-to)104-114
Number of pages11
JournalCytokine
Volume70
Issue number2
DOIs
Publication statusPublished - 2014 Dec 1

Fingerprint

Polymorphism
Stomach Neoplasms
Meta-Analysis
Tumor Necrosis Factor-alpha
Genes
Odds Ratio
Confidence Intervals
Ethnic Groups
MEDLINE
Libraries
Stomach
Carcinogenesis
Databases
DNA
Population

Keywords

  • Cytokine
  • Gastric cancer
  • Polymorphism
  • TNF-α-308
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk : A systematic review and meta-analysis. / Yang, Jong Pill; Hyun, Myung Han; Yoon, Jeong Min; Park, Min Jeong; Kim, Donghyeok; Park, Sungsoo.

In: Cytokine, Vol. 70, No. 2, 01.12.2014, p. 104-114.

Research output: Contribution to journalArticle

Yang, Jong Pill ; Hyun, Myung Han ; Yoon, Jeong Min ; Park, Min Jeong ; Kim, Donghyeok ; Park, Sungsoo. / Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk : A systematic review and meta-analysis. In: Cytokine. 2014 ; Vol. 70, No. 2. pp. 104-114.
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abstract = "Objective: Tumor necrosis factor-alpha (TNF-α) has been found to be associated with gastric carcinogenesis, but individually published results have been inconclusive. The aim of this study was to explore the relationship between the TNF-α-308 G/A polymorphism and gastric cancer risk. Methods: MEDLINE, EMBASE and the COCHRANE library databases were searched for relevant articles to identify all available data. The odds ratios (ORs) with 95{\%} confidence intervals (95{\%} CIs) from each study were used to assess the association between the TNF-α-308 G/A polymorphism and gastric cancer risk. Results: This meta-analysis included 30 studies (32 datasets) involving 7009 gastric cancer cases and 12,119 control subjects. Overall, a significant association was found between the TNF-α-308 G/A polymorphism and gastric cancer in AA. +. GA vs. GG (dominant contrast model) (OR. =. 1.20, 95{\%} CI. =. 1.07-1.34, p=. 0.001). With stratification based on ethnicity, the TNF-α-308 G/A polymorphism was correlated with gastric cancer risk in Caucasians, using the dominant contrast model (OR. =. 0.74, 95{\%} CI. =. 0.57-0.96, p=. 0.02), but not in East Asians and other ethnic groups. In the comprehensive subgroup analysis, a significant association was also found in recent articles (published after 2005), population-based high-quality studies, hospital-based high-quality studies, studies using the TaqMan method and non-cardia subgroups. However, the TNF-α-308 G/A polymorphism was not associated with specific histological types of gastric cancer risk. Conclusions: The TNF-α-308 G/A polymorphism may contribute to susceptibility to gastric cancer in Caucasians, especially for non-cardia gastric cancer, as most strongly demonstrated in high-quality studies and in studies using the TaqMan genotyping method. Furthermore, we recommend the TaqMan method as the preferred genotyping method in DNA polymorphism studies.",
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AU - Kim, Donghyeok

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N2 - Objective: Tumor necrosis factor-alpha (TNF-α) has been found to be associated with gastric carcinogenesis, but individually published results have been inconclusive. The aim of this study was to explore the relationship between the TNF-α-308 G/A polymorphism and gastric cancer risk. Methods: MEDLINE, EMBASE and the COCHRANE library databases were searched for relevant articles to identify all available data. The odds ratios (ORs) with 95% confidence intervals (95% CIs) from each study were used to assess the association between the TNF-α-308 G/A polymorphism and gastric cancer risk. Results: This meta-analysis included 30 studies (32 datasets) involving 7009 gastric cancer cases and 12,119 control subjects. Overall, a significant association was found between the TNF-α-308 G/A polymorphism and gastric cancer in AA. +. GA vs. GG (dominant contrast model) (OR. =. 1.20, 95% CI. =. 1.07-1.34, p=. 0.001). With stratification based on ethnicity, the TNF-α-308 G/A polymorphism was correlated with gastric cancer risk in Caucasians, using the dominant contrast model (OR. =. 0.74, 95% CI. =. 0.57-0.96, p=. 0.02), but not in East Asians and other ethnic groups. In the comprehensive subgroup analysis, a significant association was also found in recent articles (published after 2005), population-based high-quality studies, hospital-based high-quality studies, studies using the TaqMan method and non-cardia subgroups. However, the TNF-α-308 G/A polymorphism was not associated with specific histological types of gastric cancer risk. Conclusions: The TNF-α-308 G/A polymorphism may contribute to susceptibility to gastric cancer in Caucasians, especially for non-cardia gastric cancer, as most strongly demonstrated in high-quality studies and in studies using the TaqMan genotyping method. Furthermore, we recommend the TaqMan method as the preferred genotyping method in DNA polymorphism studies.

AB - Objective: Tumor necrosis factor-alpha (TNF-α) has been found to be associated with gastric carcinogenesis, but individually published results have been inconclusive. The aim of this study was to explore the relationship between the TNF-α-308 G/A polymorphism and gastric cancer risk. Methods: MEDLINE, EMBASE and the COCHRANE library databases were searched for relevant articles to identify all available data. The odds ratios (ORs) with 95% confidence intervals (95% CIs) from each study were used to assess the association between the TNF-α-308 G/A polymorphism and gastric cancer risk. Results: This meta-analysis included 30 studies (32 datasets) involving 7009 gastric cancer cases and 12,119 control subjects. Overall, a significant association was found between the TNF-α-308 G/A polymorphism and gastric cancer in AA. +. GA vs. GG (dominant contrast model) (OR. =. 1.20, 95% CI. =. 1.07-1.34, p=. 0.001). With stratification based on ethnicity, the TNF-α-308 G/A polymorphism was correlated with gastric cancer risk in Caucasians, using the dominant contrast model (OR. =. 0.74, 95% CI. =. 0.57-0.96, p=. 0.02), but not in East Asians and other ethnic groups. In the comprehensive subgroup analysis, a significant association was also found in recent articles (published after 2005), population-based high-quality studies, hospital-based high-quality studies, studies using the TaqMan method and non-cardia subgroups. However, the TNF-α-308 G/A polymorphism was not associated with specific histological types of gastric cancer risk. Conclusions: The TNF-α-308 G/A polymorphism may contribute to susceptibility to gastric cancer in Caucasians, especially for non-cardia gastric cancer, as most strongly demonstrated in high-quality studies and in studies using the TaqMan genotyping method. Furthermore, we recommend the TaqMan method as the preferred genotyping method in DNA polymorphism studies.

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