Abstract
The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer’s disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966–1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256–2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822–1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411–37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations.
Original language | English |
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Pages (from-to) | 825-832 |
Number of pages | 8 |
Journal | Neurological Sciences |
Volume | 36 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2015 Jun 5 |
Externally published | Yes |
Keywords
- Meta-analysis
- Polymorphism
- Rheumatoid arthritis
- Tumor necrosis factor
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health