TY - JOUR
T1 - Association between TNF-α promoter −308 A/G polymorphism and Alzheimer’s disease
T2 - a meta-analysis
AU - Lee, Young Ho
AU - Choi, Sung Jae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
N1 - Publisher Copyright:
© 2015, Springer-Verlag Italia.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/6/5
Y1 - 2015/6/5
N2 - The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer’s disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966–1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256–2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822–1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411–37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations.
AB - The aim of this study was to determine whether the tumor necrosis factor-α (TNF-α) promoter −308 A/G polymorphism is associated with susceptibility to Alzheimer’s disease (AD) in multi-ethnic populations. MEDLINE and EMBASE databases and manual literature search were used to identify published articles in which TNF-α polymorphism was determined in AD patients and control subjects. Meta-analysis was conducted on the association between the TNF-α −308 A/G polymorphism and AD using allele contrast and the recessive, dominant, and additive models. A total of 16 studies involving 3,826 AD patients and 4,327 control subjects were examined. The meta-analysis showed no association between the TNF-α −308 A allele and AD when all the subjects were considered [odds ratio (OR) = 1.275, 95 % CI 0.966–1.685, p = 0.087]. After stratification by ethnicity, the meta-analysis indicated that the A allele is significantly associated with AD in East Asian (OR = 1.743, 95 % CI 1.256–2.418, p = 0.001), but not in the European (OR = 0.963, 95 % CI 0.822–1.128, p = 0.637) or Middle Eastern populations (OR = 3.921, 95 % CI 0.411–37.42, p = 0.235). Meta-analysis under dominant, recessive, and additive models also showed a similar pattern of results as with the A allele. This meta-analysis shows that the TNF-α −308 A/G polymorphism may represent a significant risk factor for AD in East Asians but not in the European or Middle Eastern populations.
KW - Meta-analysis
KW - Polymorphism
KW - Rheumatoid arthritis
KW - Tumor necrosis factor
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U2 - 10.1007/s10072-015-2102-8
DO - 10.1007/s10072-015-2102-8
M3 - Review article
C2 - 25647294
AN - SCOPUS:84930382279
VL - 36
SP - 825
EP - 832
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -