Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women

Jaewon Yang, Moon Soo Lee, So Hee Lee, Boung Chul Lee, Seung Hyun Kim, Sook Haeng Joe, In Kwa Jung, Ihn Geun Choi, Byung Joo Ham

Research output: Contribution to journalArticle

13 Citations (Scopus)


Background/Aims: It has been suggested that the serotonergic systems are associated with anger and aggressive behaviors. We investigated the association between several single nucleotide polymorphisms in the serotonergic genes and anger-related personality traits. Methods: A total of 228 healthy female Korean women participated in this study. All subjects were assessed with the State-Trait Anger Expression Inventory (STAXI) and were genotyped for 3 polymorphisms: serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 1 (TPH1) A218C, and TPH2 G-703T. Results: The Anger Expression-Out (AX-Out) subscale scores of the STAXI differed significantly between the genotypes for the TPH2 G-703T polymorphism (F = 4.825, p = 0.009). G/G homozygous subjects scored significantly higher on the AX-Out subscale than those with the G/T genotype. However, no significant differences were observed in the relationships between the STAXI subscale scores of subjects with other polymorphisms. Conclusions: This study suggests that the TPH2 G-703T polymorphism might contribute to anger-related traits, especially to the expression of anger.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
Issue number3
Publication statusPublished - 2010 Aug 1



  • Anger
  • Polymorphism
  • Tryptophan hydroxylase 2

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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