Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women

Jaewon Yang, Moon-Soo Lee, So H. Lee, Boung Chul Lee, Seung Hyun Kim, Sook Haeng Joe, In K. Jung, Ihn Geun Choi, Byung-Joo Ham

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: It has been suggested that the serotonergic systems are associated with anger and aggressive behaviors. We investigated the association between several single nucleotide polymorphisms in the serotonergic genes and anger-related personality traits. Methods: A total of 228 healthy female Korean women participated in this study. All subjects were assessed with the State-Trait Anger Expression Inventory (STAXI) and were genotyped for 3 polymorphisms: serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 1 (TPH1) A218C, and TPH2 G-703T. Results: The Anger Expression-Out (AX-Out) subscale scores of the STAXI differed significantly between the genotypes for the TPH2 G-703T polymorphism (F = 4.825, p = 0.009). G/G homozygous subjects scored significantly higher on the AX-Out subscale than those with the G/T genotype. However, no significant differences were observed in the relationships between the STAXI subscale scores of subjects with other polymorphisms. Conclusions: This study suggests that the TPH2 G-703T polymorphism might contribute to anger-related traits, especially to the expression of anger.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalNeuropsychobiology
Volume62
Issue number3
DOIs
Publication statusPublished - 2010 Aug 1

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Tryptophan Hydroxylase
Anger
Personality
Equipment and Supplies
Genotype
Serotonin Plasma Membrane Transport Proteins
Genes
Single Nucleotide Polymorphism

Keywords

  • Anger
  • Polymorphism
  • Tryptophan hydroxylase 2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology

Cite this

Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women. / Yang, Jaewon; Lee, Moon-Soo; Lee, So H.; Lee, Boung Chul; Kim, Seung Hyun; Joe, Sook Haeng; Jung, In K.; Choi, Ihn Geun; Ham, Byung-Joo.

In: Neuropsychobiology, Vol. 62, No. 3, 01.08.2010, p. 158-163.

Research output: Contribution to journalArticle

Yang, Jaewon ; Lee, Moon-Soo ; Lee, So H. ; Lee, Boung Chul ; Kim, Seung Hyun ; Joe, Sook Haeng ; Jung, In K. ; Choi, Ihn Geun ; Ham, Byung-Joo. / Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women. In: Neuropsychobiology. 2010 ; Vol. 62, No. 3. pp. 158-163.
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