Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: A meta-analysis

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Abstract

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α -308 A/G polymorphism and three studies for the TNF-α -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 % CI = 0.447-0.907, p = 0.013; OR = 0.403, 95 % CI = 0.204-0.707, p = 0.009; OR = 1.818, 95; % CI = 1.036-3.189, p = 0.037). The meta-analysis showed no association between the TNF-α -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 % CI = 1.081-5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR = 1.585, 95 % CI = 1.030-2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 % CI = 1.254-3.577, p = 0.005). This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.

Original languageEnglish
Pages (from-to)5191-5203
Number of pages13
JournalMolecular Biology Reports
Volume40
Issue number8
DOIs
Publication statusPublished - 2013 Aug 1

Fingerprint

Periodontitis
Periodontal Diseases
Meta-Analysis
Interleukin-6
Tumor Necrosis Factor-alpha
Chronic Periodontitis
Population
Alleles
PubMed

Keywords

  • IL-6
  • Meta-analysis
  • Periodontitis
  • Polymorphism
  • TNF-α

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

@article{c8c6dc6b70e040feb2357b5484ad3be8,
title = "Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: A meta-analysis",
abstract = "The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α -308 A/G polymorphism and three studies for the TNF-α -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 {\%} CI = 0.447-0.907, p = 0.013; OR = 0.403, 95 {\%} CI = 0.204-0.707, p = 0.009; OR = 1.818, 95; {\%} CI = 1.036-3.189, p = 0.037). The meta-analysis showed no association between the TNF-α -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 {\%} CI = 1.081-5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR = 1.585, 95 {\%} CI = 1.030-2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 {\%} CI = 1.254-3.577, p = 0.005). This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.",
keywords = "IL-6, Meta-analysis, Periodontitis, Polymorphism, TNF-α",
author = "Song, {Gwan Gyu} and Sungjae Choi and Ji, {Jong Dae} and Lee, {Young Ho}",
year = "2013",
month = "8",
day = "1",
doi = "10.1007/s11033-013-2621-4",
language = "English",
volume = "40",
pages = "5191--5203",
journal = "Molecular Biology Reports",
issn = "0301-4851",
publisher = "Springer Netherlands",
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TY - JOUR

T1 - Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α -308 A/G polymorphism and three studies for the TNF-α -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 % CI = 0.447-0.907, p = 0.013; OR = 0.403, 95 % CI = 0.204-0.707, p = 0.009; OR = 1.818, 95; % CI = 1.036-3.189, p = 0.037). The meta-analysis showed no association between the TNF-α -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 % CI = 1.081-5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR = 1.585, 95 % CI = 1.030-2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 % CI = 1.254-3.577, p = 0.005). This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.

AB - The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α -308 A/G polymorphism and three studies for the TNF-α -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 % CI = 0.447-0.907, p = 0.013; OR = 0.403, 95 % CI = 0.204-0.707, p = 0.009; OR = 1.818, 95; % CI = 1.036-3.189, p = 0.037). The meta-analysis showed no association between the TNF-α -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 % CI = 1.081-5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR = 1.585, 95 % CI = 1.030-2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 % CI = 1.254-3.577, p = 0.005). This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.

KW - IL-6

KW - Meta-analysis

KW - Periodontitis

KW - Polymorphism

KW - TNF-α

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U2 - 10.1007/s11033-013-2621-4

DO - 10.1007/s11033-013-2621-4

M3 - Article

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AN - SCOPUS:84881142999

VL - 40

SP - 5191

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JO - Molecular Biology Reports

JF - Molecular Biology Reports

SN - 0301-4851

IS - 8

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