TY - JOUR
T1 - Association between vascular inflammation and non-alcoholic fatty liver disease
T2 - Analysis by 18F-fluorodeoxyglucose positron emission tomography
AU - Lee, Hyun Jung
AU - Lee, Chang-Hee
AU - Kim, Sungeun
AU - Hwang, Soon Young
AU - Hong, Ho Cheol
AU - Choi, Hyuk Soon
AU - Chung, Hye Soo
AU - Yoo, Hye Jin
AU - Seo, Ji A
AU - Kim, Sin Gon
AU - Kim, Nan Hee
AU - Baik, Sei-Hyun
AU - Choi, Dong Seop
AU - Choi, Kyung Mook
N1 - Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education, Science and Technology ( 2012006363 ) (K.M.C.), the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea (K.M.C. and S.H.B.) (HI10V-0007-010,013), and a grant from Korea University (K.M.C.).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background Growing evidence suggests that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease as well as metabolic syndrome. FDG-PET is a novel imaging technique that detects vascular inflammation, which may reflect rupture-prone vulnerable atherosclerotic plaques. Methods Vascular inflammation was measured as the maximum target-to-background ratio (maxTBR), along with various cardiometabolic risk factors in 51 subjects with NAFLD, and compared with 100 age- and gender-matched subjects without NAFLD. The liver attenuation index (LAI), which was measured using computed tomography, was used as a parameter for the diagnosis of NAFLD. Results After adjusting for age and sex, both maxTBR and LAI values were associated with several cardiometabolic risk parameters. Furthermore, there was a significant inter-relationship between LAI and maxTBR values (r = − 0.227, P = 0.005). Individuals with NAFLD had higher maxTBR values than those without NAFLD (P = 0.026), although their carotid intima–media thickness (CIMT) values did not differ. The proportion of subjects with NAFLD showed a step-wise increment following the tertiles of maxTBR values (P for trend = 0.015). In multiple logistic regression analysis, maxTBR tertiles were independently associated with NAFLD after adjusting for age, gender, systolic blood pressure, triglycerides, HDL-cholesterol, glucose, BUN, creatinine and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.030). However, their relationship was attenuated after further adjustment for waist circumference or high sensitive C-reactive protein. Conclusion Patients with NAFLD have an increased risk for vascular inflammation as measured via FDG-PET/CT even without difference in CIMT. (Clinical trials No. NCT01958411, http://www.clinicaltrials.gov/)
AB - Background Growing evidence suggests that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease as well as metabolic syndrome. FDG-PET is a novel imaging technique that detects vascular inflammation, which may reflect rupture-prone vulnerable atherosclerotic plaques. Methods Vascular inflammation was measured as the maximum target-to-background ratio (maxTBR), along with various cardiometabolic risk factors in 51 subjects with NAFLD, and compared with 100 age- and gender-matched subjects without NAFLD. The liver attenuation index (LAI), which was measured using computed tomography, was used as a parameter for the diagnosis of NAFLD. Results After adjusting for age and sex, both maxTBR and LAI values were associated with several cardiometabolic risk parameters. Furthermore, there was a significant inter-relationship between LAI and maxTBR values (r = − 0.227, P = 0.005). Individuals with NAFLD had higher maxTBR values than those without NAFLD (P = 0.026), although their carotid intima–media thickness (CIMT) values did not differ. The proportion of subjects with NAFLD showed a step-wise increment following the tertiles of maxTBR values (P for trend = 0.015). In multiple logistic regression analysis, maxTBR tertiles were independently associated with NAFLD after adjusting for age, gender, systolic blood pressure, triglycerides, HDL-cholesterol, glucose, BUN, creatinine and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.030). However, their relationship was attenuated after further adjustment for waist circumference or high sensitive C-reactive protein. Conclusion Patients with NAFLD have an increased risk for vascular inflammation as measured via FDG-PET/CT even without difference in CIMT. (Clinical trials No. NCT01958411, http://www.clinicaltrials.gov/)
KW - Inflammation
KW - Nonalcoholic fatty liver disease
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85000842731&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2016.11.004
DO - 10.1016/j.metabol.2016.11.004
M3 - Article
C2 - 28081780
AN - SCOPUS:85000842731
VL - 67
SP - 72
EP - 79
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
ER -