Abstract
Purpose: Vitamin D deficiency is a condition widespread throughout the world. Recent studies have suggested that vitamin D deficiency was associated with obesity and metabolic syndrome. The purpose of the study was to examine the relationship between vitamin D deficiency and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods: The data were obtained from the Korean National Health and Nutrition Examination Survey from 2008-2014. A total of 3,878 adolescents were included in the study. Vitamin D deficiency was defined as a 25-hydroxyvitamin D concentration < 20 ng/mL and suspected NAFLD was defined as an alanine transaminase concentration > 30 U/L. Results: Vitamin D deficiency was noted in 78.9% of the studied population. Age, body mass index, waist circumference, and blood pressure, glucose, cholesterol, and triglyceride levels were significantly higher in adolescents with suspected NAFLD than in adolescents without suspected NAFLD, while the mean vitamin D level was significantly lower in adolescents with suspected NAFLD. The multivariate-adjusted odds of suspected NAFLD were higher with increased age, male gender, obesity, and metabolic syndrome. Individuals with vitamin D deficiency were at higher risk of suspected NAFLD (odds ratio, 1.77; 95% confidence interval, 1.07-2.95) after adjusting for age, gender, obesity, and metabolic syndrome. Conclusion: Vitamin D deficiency was associated with suspected NAFLD, independent of obesity and metabolic syndrome, in adolescents.
| Original language | English |
|---|---|
| Pages (from-to) | 233-241 |
| Number of pages | 9 |
| Journal | Pediatric Gastroenterology, Hepatology and Nutrition |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2019 May 1 |
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Keywords
- Adolescent
- Alanine transaminase
- Children
- Nonalcoholic fatty liver disease
- Obesity
- Vitamin D deficiency
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hepatology
- Gastroenterology
Cite this
Association between vitamin D deficiency and suspected nonalcoholic fatty liver disease in an adolescent population. / Cho, Young Hoon; Kim, Ju Whi; Shim, Jung Ok; Yang, Hye Ran; Chang, Ju Young; Moon, Jin Soo; Ko, Jae Sung.
In: Pediatric Gastroenterology, Hepatology and Nutrition, Vol. 22, No. 3, 01.05.2019, p. 233-241.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between vitamin D deficiency and suspected nonalcoholic fatty liver disease in an adolescent population
AU - Cho, Young Hoon
AU - Kim, Ju Whi
AU - Shim, Jung Ok
AU - Yang, Hye Ran
AU - Chang, Ju Young
AU - Moon, Jin Soo
AU - Ko, Jae Sung
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Purpose: Vitamin D deficiency is a condition widespread throughout the world. Recent studies have suggested that vitamin D deficiency was associated with obesity and metabolic syndrome. The purpose of the study was to examine the relationship between vitamin D deficiency and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods: The data were obtained from the Korean National Health and Nutrition Examination Survey from 2008-2014. A total of 3,878 adolescents were included in the study. Vitamin D deficiency was defined as a 25-hydroxyvitamin D concentration < 20 ng/mL and suspected NAFLD was defined as an alanine transaminase concentration > 30 U/L. Results: Vitamin D deficiency was noted in 78.9% of the studied population. Age, body mass index, waist circumference, and blood pressure, glucose, cholesterol, and triglyceride levels were significantly higher in adolescents with suspected NAFLD than in adolescents without suspected NAFLD, while the mean vitamin D level was significantly lower in adolescents with suspected NAFLD. The multivariate-adjusted odds of suspected NAFLD were higher with increased age, male gender, obesity, and metabolic syndrome. Individuals with vitamin D deficiency were at higher risk of suspected NAFLD (odds ratio, 1.77; 95% confidence interval, 1.07-2.95) after adjusting for age, gender, obesity, and metabolic syndrome. Conclusion: Vitamin D deficiency was associated with suspected NAFLD, independent of obesity and metabolic syndrome, in adolescents.
AB - Purpose: Vitamin D deficiency is a condition widespread throughout the world. Recent studies have suggested that vitamin D deficiency was associated with obesity and metabolic syndrome. The purpose of the study was to examine the relationship between vitamin D deficiency and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods: The data were obtained from the Korean National Health and Nutrition Examination Survey from 2008-2014. A total of 3,878 adolescents were included in the study. Vitamin D deficiency was defined as a 25-hydroxyvitamin D concentration < 20 ng/mL and suspected NAFLD was defined as an alanine transaminase concentration > 30 U/L. Results: Vitamin D deficiency was noted in 78.9% of the studied population. Age, body mass index, waist circumference, and blood pressure, glucose, cholesterol, and triglyceride levels were significantly higher in adolescents with suspected NAFLD than in adolescents without suspected NAFLD, while the mean vitamin D level was significantly lower in adolescents with suspected NAFLD. The multivariate-adjusted odds of suspected NAFLD were higher with increased age, male gender, obesity, and metabolic syndrome. Individuals with vitamin D deficiency were at higher risk of suspected NAFLD (odds ratio, 1.77; 95% confidence interval, 1.07-2.95) after adjusting for age, gender, obesity, and metabolic syndrome. Conclusion: Vitamin D deficiency was associated with suspected NAFLD, independent of obesity and metabolic syndrome, in adolescents.
KW - Adolescent
KW - Alanine transaminase
KW - Children
KW - Nonalcoholic fatty liver disease
KW - Obesity
KW - Vitamin D deficiency
UR - http://www.scopus.com/inward/record.url?scp=85066123144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066123144&partnerID=8YFLogxK
U2 - 10.5223/pghn.2019.22.3.233
DO - 10.5223/pghn.2019.22.3.233
M3 - Article
AN - SCOPUS:85066123144
VL - 22
SP - 233
EP - 241
JO - Pediatric Gastroenterology, Hepatology and Nutrition
JF - Pediatric Gastroenterology, Hepatology and Nutrition
SN - 2234-8646
IS - 3
ER -