Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: A population-based study

Kyu Man Han, Heon Jeong Lee, Leen Kim, Ho Kyoung Yoon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Study Objectives: To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a serum inflammatory maker—in adults Methods: Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. Results: The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Conclusions: Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
Issue number8
Publication statusPublished - 2020 Aug 1


  • High-sensitivity C-reactive protein
  • Inflammation
  • Obesity
  • Sleep duration
  • Weekend catch-up sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)


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