Association between work time loss and quality of life in patients with Herpes Zoster

A pooled analysis of the MASTER studies

Emmanouil Rampakakis, Melissa Stutz, Kosuke Kawai, Tsen Fang Tsai, Hee-Jin Cheong, Jittima Dhitavat, Alejandro Ortiz-Covarrubias, Miguel Cashat-Cruz, Homero Monsanto, Kelly D. Johnson, John S. Sampalis, Camilo J. Acosta

Research output: Contribution to journalArticle

Abstract

Background: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL). Methods: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia. A total of 428 HZ patients engaged in full or part time work were included. WTL, defined as missing≥1 partial or full work day, and work effectiveness, reported on a scale of 0-100%, were evaluated with the Work and Productivity Questionnaire (WPQ). The Pearson product-moment correlation was used to assess the correlation between work effectiveness and HRQoL. Mixed models with repeated measures assessed the relationship between HZ-related WTL over a 6-month follow-up period, and HRQoL, as evaluated by the EQ-5D. Additional predictors of HRQoL were also identified. Results: Overall, 57.7% of respondents reported WTL. Mean (SD) percent work effectiveness of patients in the WTL group was significantly lower compared to non-WTL (NWTL) patients at baseline [50.3 (31.6) vs. 71.4 (27.8); p<0.001]. Patients in the WTL group also reported lower health utility scores at baseline and overall than their NWTL counterparts, with WTL identified as an independent negative predictor of both the EQ-5D summary scores and the EQ-5D VAS (p<0.001). Decrease in work effectiveness was negatively associated with HRQoL overall (p<0.001). Predictors of lower HRQoL were worst Zoster Brief Pain Inventory (ZBPI) pain score, the presence of HZ complications and country income (predictor of EQ-5D VAS only). Conclusions: HZ adversely impacts the work and productive life of actively employed individuals. In turn, HZ-related reductions in work effectiveness and work time are associated with a negative effect on HRQoL.

Original languageEnglish
Article number11
JournalHealth and Quality of Life Outcomes
Volume15
Issue number1
DOIs
Publication statusPublished - 2017 Jan 18

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Herpes Zoster
Quality of Life
Pain
Absenteeism
Latin America
Health
North America

Keywords

  • Herpes Zoster
  • Observational study
  • Quality of life
  • Work

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Association between work time loss and quality of life in patients with Herpes Zoster : A pooled analysis of the MASTER studies. / Rampakakis, Emmanouil; Stutz, Melissa; Kawai, Kosuke; Tsai, Tsen Fang; Cheong, Hee-Jin; Dhitavat, Jittima; Ortiz-Covarrubias, Alejandro; Cashat-Cruz, Miguel; Monsanto, Homero; Johnson, Kelly D.; Sampalis, John S.; Acosta, Camilo J.

In: Health and Quality of Life Outcomes, Vol. 15, No. 1, 11, 18.01.2017.

Research output: Contribution to journalArticle

Rampakakis, E, Stutz, M, Kawai, K, Tsai, TF, Cheong, H-J, Dhitavat, J, Ortiz-Covarrubias, A, Cashat-Cruz, M, Monsanto, H, Johnson, KD, Sampalis, JS & Acosta, CJ 2017, 'Association between work time loss and quality of life in patients with Herpes Zoster: A pooled analysis of the MASTER studies', Health and Quality of Life Outcomes, vol. 15, no. 1, 11. https://doi.org/10.1186/s12955-017-0588-x
Rampakakis, Emmanouil ; Stutz, Melissa ; Kawai, Kosuke ; Tsai, Tsen Fang ; Cheong, Hee-Jin ; Dhitavat, Jittima ; Ortiz-Covarrubias, Alejandro ; Cashat-Cruz, Miguel ; Monsanto, Homero ; Johnson, Kelly D. ; Sampalis, John S. ; Acosta, Camilo J. / Association between work time loss and quality of life in patients with Herpes Zoster : A pooled analysis of the MASTER studies. In: Health and Quality of Life Outcomes. 2017 ; Vol. 15, No. 1.
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abstract = "Background: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL). Methods: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia. A total of 428 HZ patients engaged in full or part time work were included. WTL, defined as missing≥1 partial or full work day, and work effectiveness, reported on a scale of 0-100{\%}, were evaluated with the Work and Productivity Questionnaire (WPQ). The Pearson product-moment correlation was used to assess the correlation between work effectiveness and HRQoL. Mixed models with repeated measures assessed the relationship between HZ-related WTL over a 6-month follow-up period, and HRQoL, as evaluated by the EQ-5D. Additional predictors of HRQoL were also identified. Results: Overall, 57.7{\%} of respondents reported WTL. Mean (SD) percent work effectiveness of patients in the WTL group was significantly lower compared to non-WTL (NWTL) patients at baseline [50.3 (31.6) vs. 71.4 (27.8); p<0.001]. Patients in the WTL group also reported lower health utility scores at baseline and overall than their NWTL counterparts, with WTL identified as an independent negative predictor of both the EQ-5D summary scores and the EQ-5D VAS (p<0.001). Decrease in work effectiveness was negatively associated with HRQoL overall (p<0.001). Predictors of lower HRQoL were worst Zoster Brief Pain Inventory (ZBPI) pain score, the presence of HZ complications and country income (predictor of EQ-5D VAS only). Conclusions: HZ adversely impacts the work and productive life of actively employed individuals. In turn, HZ-related reductions in work effectiveness and work time are associated with a negative effect on HRQoL.",
keywords = "Herpes Zoster, Observational study, Quality of life, Work",
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T2 - A pooled analysis of the MASTER studies

AU - Rampakakis, Emmanouil

AU - Stutz, Melissa

AU - Kawai, Kosuke

AU - Tsai, Tsen Fang

AU - Cheong, Hee-Jin

AU - Dhitavat, Jittima

AU - Ortiz-Covarrubias, Alejandro

AU - Cashat-Cruz, Miguel

AU - Monsanto, Homero

AU - Johnson, Kelly D.

AU - Sampalis, John S.

AU - Acosta, Camilo J.

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N2 - Background: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL). Methods: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia. A total of 428 HZ patients engaged in full or part time work were included. WTL, defined as missing≥1 partial or full work day, and work effectiveness, reported on a scale of 0-100%, were evaluated with the Work and Productivity Questionnaire (WPQ). The Pearson product-moment correlation was used to assess the correlation between work effectiveness and HRQoL. Mixed models with repeated measures assessed the relationship between HZ-related WTL over a 6-month follow-up period, and HRQoL, as evaluated by the EQ-5D. Additional predictors of HRQoL were also identified. Results: Overall, 57.7% of respondents reported WTL. Mean (SD) percent work effectiveness of patients in the WTL group was significantly lower compared to non-WTL (NWTL) patients at baseline [50.3 (31.6) vs. 71.4 (27.8); p<0.001]. Patients in the WTL group also reported lower health utility scores at baseline and overall than their NWTL counterparts, with WTL identified as an independent negative predictor of both the EQ-5D summary scores and the EQ-5D VAS (p<0.001). Decrease in work effectiveness was negatively associated with HRQoL overall (p<0.001). Predictors of lower HRQoL were worst Zoster Brief Pain Inventory (ZBPI) pain score, the presence of HZ complications and country income (predictor of EQ-5D VAS only). Conclusions: HZ adversely impacts the work and productive life of actively employed individuals. In turn, HZ-related reductions in work effectiveness and work time are associated with a negative effect on HRQoL.

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