Association of a progesterone receptor gene +331 G/A polymorphism with breast cancer risk: a meta-analysis

Dae Sik Yang, Hwa Jung Sung, Ok Hee Woo, Kyong Hwa Park, Sang Uk Woo, Ae Ree Kim, Eun Sook Lee, Jae Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Published studies on the association between the progesterone receptor gene +331 G/A polymorphism and breast cancer risk are inconclusive, and meta-analysis is required to verify the association. Six studies, including a total of 6,849 cases and 6,589 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the AG + AA variant genotype was not associated with a significantly elevated breast cancer risk [odds ratio (OR) = 1.11; 95% confidence interval (95%CI) = 0.99-1.24; P = 0.071]. However, subgroup analysis revealed that the AG + AA variant genotype was associated with an increased risk of breast cancer in American (OR = 1.32; 95%CI = 1.10-1.58; P = 0.003), but not in European or Australian. We could carefully suggest that the progesterone receptor promoter +331 G/A variant polymorphism might increase breast cancer risk, and this effect appeared to be more prominent in Americans than in Europeans and Australians.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume196
Issue number2
DOIs
Publication statusPublished - 2010 Jan 15

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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