Association of a single nucleotide polymorphism in the 5' upstream region of the porcine myosin heavy chain 4 gene with meat quality traits in pigs

Eun Seok Cho, Kyung Tai Lee, Jun Mo Kim, Si Woo Lee, Hyeon Jeong Jeon, Seung Hwan Lee, Ki Chang Hong, Tae Hun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We identified a potential molecular marker associated with meat quality traits in the myosin heavy chain 4, MYH4 gene of Landrace pigs. Sequencing revealed a single nucleotide polymorphism (SNP; g.-1398G>T) in the 5' upstream region of MYH4. It was significantly associated with the number of type IIa muscle fibers and water-holding capacity based on filter-paper fluid uptake. The GG genotype groups had a greater number of type IIa fibers and a larger area composed of type IIa fibers than the other genotype group (P = 0.004 and P = 0.061, respectively). Expression level of MYH4 gene in the genotype TT or GT was higher than in genotype of GG (P <0.0001). The T allele may enhance expression level of MYH4 gene and then the portion of IIb type fiber in the muscle be increased by the T allelle. Therefore, we suggest that the g.-1398G>T in the 5' upstream region of the porcine MYH4 may be used as a molecular marker for meat quality traits, although its functional effect is not defined yet.

Original languageEnglish
Pages (from-to)330-335
Number of pages6
JournalAnimal Science Journal
Volume87
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Myosin Heavy Chains
myosin heavy chains
Meat
meat quality
single nucleotide polymorphism
Single Nucleotide Polymorphism
Swine
Genotype
swine
genotype
Genes
dietary fiber
genes
genetic markers
muscle fibers
water holding capacity
landraces
Muscles
Water

Keywords

  • Meat quality
  • Muscle fiber composition
  • Myosin heavy chain 4 gene
  • Pig
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Association of a single nucleotide polymorphism in the 5' upstream region of the porcine myosin heavy chain 4 gene with meat quality traits in pigs. / Cho, Eun Seok; Lee, Kyung Tai; Kim, Jun Mo; Lee, Si Woo; Jeon, Hyeon Jeong; Lee, Seung Hwan; Hong, Ki Chang; Kim, Tae Hun.

In: Animal Science Journal, Vol. 87, No. 3, 01.03.2016, p. 330-335.

Research output: Contribution to journalArticle

Cho, Eun Seok ; Lee, Kyung Tai ; Kim, Jun Mo ; Lee, Si Woo ; Jeon, Hyeon Jeong ; Lee, Seung Hwan ; Hong, Ki Chang ; Kim, Tae Hun. / Association of a single nucleotide polymorphism in the 5' upstream region of the porcine myosin heavy chain 4 gene with meat quality traits in pigs. In: Animal Science Journal. 2016 ; Vol. 87, No. 3. pp. 330-335.
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