Association of a TGF-β1 gene -509 C/T polymorphism with breast cancer risk: A meta-analysis

Sang Uk Woo, Kyong Hwa Park, Ok Hee Woo, Dae Sik Yang, Ae Ree Kim, Eun Sook Lee, Jae Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Transforming growth factor-β1 (TGF-β1) is negative regulator of cell proliferation and the cell cycle, and plasma levels of TGF-β1 are twice as high in TGF-β1 -509 T homozygotes as in -509 C homozygotes. Published studies on the association between the TGF-β1 gene -509 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. We performed a meta-analysis of four studies, including a total of 5,986 cases and 6,829 controls. Our pooled results indicate that the TGF-β1 gene -509 C/T polymorphism is not associated with breast cancer risk in a TT versus CC codominant (OR = 1.08; 95% CI = 0.87-1.34; P = 0.494), in a CT versus CC codominant (OR = 1.02; 95% CI = 0.94-1.10; P = 0.686), recessive (OR = 0.92; 95% CI = 0.83-1.03; P = 0.157), and dominant (OR = 1.03; 95% CI = 0.96-1.11; P = 0.439) models. Conclusively, this meta-analysis suggests that the TGF-β1 gene -509 T allele polymorphism does not decrease breast cancer risk.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalBreast Cancer Research and Treatment
Volume124
Issue number2
DOIs
Publication statusPublished - 2010 Nov

Keywords

  • -509 C/T polymorphism
  • Breast cancer risk
  • Meta-analysis
  • TGF-β1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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