Association of a TGF-β1 gene -509 C/T polymorphism with breast cancer risk: A meta-analysis

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14 Citations (Scopus)

Abstract

Transforming growth factor-β1 (TGF-β1) is negative regulator of cell proliferation and the cell cycle, and plasma levels of TGF-β1 are twice as high in TGF-β1 -509 T homozygotes as in -509 C homozygotes. Published studies on the association between the TGF-β1 gene -509 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. We performed a meta-analysis of four studies, including a total of 5,986 cases and 6,829 controls. Our pooled results indicate that the TGF-β1 gene -509 C/T polymorphism is not associated with breast cancer risk in a TT versus CC codominant (OR = 1.08; 95% CI = 0.87-1.34; P = 0.494), in a CT versus CC codominant (OR = 1.02; 95% CI = 0.94-1.10; P = 0.686), recessive (OR = 0.92; 95% CI = 0.83-1.03; P = 0.157), and dominant (OR = 1.03; 95% CI = 0.96-1.11; P = 0.439) models. Conclusively, this meta-analysis suggests that the TGF-β1 gene -509 T allele polymorphism does not decrease breast cancer risk.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalBreast Cancer Research and Treatment
Volume124
Issue number2
DOIs
Publication statusPublished - 2010 Nov 1

Keywords

  • -509 C/T polymorphism
  • Breast cancer risk
  • Meta-analysis
  • TGF-β1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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