Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: A meta-analysis

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Abstract

Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75-1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalBreast Cancer Research and Treatment
Volume125
Issue number3
DOIs
Publication statusPublished - 2011 Feb

Keywords

  • 936 C/T polymorphism
  • Breast cancer risk
  • Meta-analysis
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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