Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type

Seung Ku Lee, Dae Wui Yoon, Jin Kwan Kim, Si Woo Lee, Jong Yeol Kim, Sun Ha Jee, Inkyung Baik, Chol Shin

Research output: Contribution to journalArticle

Abstract

Introduction: Mounting evidence indicates a significant relationship between Sasang constitutional types (SCTs) and metabolic syndrome (MetS), and between metabolic hormones and risk of MetS. However, studies have not yet examined whether the impact of metabolic hormones on MetS differs according to SCT. The aim of this study was to investigate whether the association of adiponectin, ghrelin, leptin with MetS and metabolic components is affected by SCTs. Methods: A total of 2370 subjects (1201 men and 1169 women) who participated in the Korean Genome and Epidemiology Study-Ansan cohort between 2007 and 2008 and completed the health-related questionnaire, anthropometric evaluation, and biochemical measurements were included in the analysis. Each constitutional type was defined using an integrated diagnostic method. Total adiponectin, ghrelin, and leptin levels were determined by enzyme-linked immunosorbent assay or radioimmunoassay. Results: Tae-eum (TE) type had the highest frequency of MetS (29.9%). In multivariate logistic regression analysis adjusted for possible confounders, adiponectin (OR = 0.88, 95% CI: 0.84–0.92; P < 0.0001) and leptin levels (OR = 1.05, 95% CI: 1.01–1.08; P = 0.015) were significantly associated with MetS in TE type, whereas only adiponectin levels were significantly associated with MetS in So-yang type (OR = 0.81, 95% CI: 0.73–0.90; P < 0.0001). Ghrelin levels were not significantly associated with MetS in all SCTs. Conclusions: This population-based study showed different association of adiponectin, ghrelin, and leptin with MetS and its components according to SCT.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalEuropean Journal of Integrative Medicine
Volume22
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Ghrelin
Adiponectin
Leptin
Hormones
Radioimmunoassay
Epidemiology
Cohort Studies
Logistic Models
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Genome
Health

Keywords

  • Adiponectin
  • Ghrelin
  • Leptin
  • Metabolic syndrome
  • Sasang constitutional types

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type. / Lee, Seung Ku; Yoon, Dae Wui; Kim, Jin Kwan; Lee, Si Woo; Kim, Jong Yeol; Jee, Sun Ha; Baik, Inkyung; Shin, Chol.

In: European Journal of Integrative Medicine, Vol. 22, 01.09.2018, p. 16-21.

Research output: Contribution to journalArticle

Lee, Seung Ku ; Yoon, Dae Wui ; Kim, Jin Kwan ; Lee, Si Woo ; Kim, Jong Yeol ; Jee, Sun Ha ; Baik, Inkyung ; Shin, Chol. / Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type. In: European Journal of Integrative Medicine. 2018 ; Vol. 22. pp. 16-21.
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abstract = "Introduction: Mounting evidence indicates a significant relationship between Sasang constitutional types (SCTs) and metabolic syndrome (MetS), and between metabolic hormones and risk of MetS. However, studies have not yet examined whether the impact of metabolic hormones on MetS differs according to SCT. The aim of this study was to investigate whether the association of adiponectin, ghrelin, leptin with MetS and metabolic components is affected by SCTs. Methods: A total of 2370 subjects (1201 men and 1169 women) who participated in the Korean Genome and Epidemiology Study-Ansan cohort between 2007 and 2008 and completed the health-related questionnaire, anthropometric evaluation, and biochemical measurements were included in the analysis. Each constitutional type was defined using an integrated diagnostic method. Total adiponectin, ghrelin, and leptin levels were determined by enzyme-linked immunosorbent assay or radioimmunoassay. Results: Tae-eum (TE) type had the highest frequency of MetS (29.9{\%}). In multivariate logistic regression analysis adjusted for possible confounders, adiponectin (OR = 0.88, 95{\%} CI: 0.84–0.92; P < 0.0001) and leptin levels (OR = 1.05, 95{\%} CI: 1.01–1.08; P = 0.015) were significantly associated with MetS in TE type, whereas only adiponectin levels were significantly associated with MetS in So-yang type (OR = 0.81, 95{\%} CI: 0.73–0.90; P < 0.0001). Ghrelin levels were not significantly associated with MetS in all SCTs. Conclusions: This population-based study showed different association of adiponectin, ghrelin, and leptin with MetS and its components according to SCT.",
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TY - JOUR

T1 - Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type

AU - Lee, Seung Ku

AU - Yoon, Dae Wui

AU - Kim, Jin Kwan

AU - Lee, Si Woo

AU - Kim, Jong Yeol

AU - Jee, Sun Ha

AU - Baik, Inkyung

AU - Shin, Chol

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Introduction: Mounting evidence indicates a significant relationship between Sasang constitutional types (SCTs) and metabolic syndrome (MetS), and between metabolic hormones and risk of MetS. However, studies have not yet examined whether the impact of metabolic hormones on MetS differs according to SCT. The aim of this study was to investigate whether the association of adiponectin, ghrelin, leptin with MetS and metabolic components is affected by SCTs. Methods: A total of 2370 subjects (1201 men and 1169 women) who participated in the Korean Genome and Epidemiology Study-Ansan cohort between 2007 and 2008 and completed the health-related questionnaire, anthropometric evaluation, and biochemical measurements were included in the analysis. Each constitutional type was defined using an integrated diagnostic method. Total adiponectin, ghrelin, and leptin levels were determined by enzyme-linked immunosorbent assay or radioimmunoassay. Results: Tae-eum (TE) type had the highest frequency of MetS (29.9%). In multivariate logistic regression analysis adjusted for possible confounders, adiponectin (OR = 0.88, 95% CI: 0.84–0.92; P < 0.0001) and leptin levels (OR = 1.05, 95% CI: 1.01–1.08; P = 0.015) were significantly associated with MetS in TE type, whereas only adiponectin levels were significantly associated with MetS in So-yang type (OR = 0.81, 95% CI: 0.73–0.90; P < 0.0001). Ghrelin levels were not significantly associated with MetS in all SCTs. Conclusions: This population-based study showed different association of adiponectin, ghrelin, and leptin with MetS and its components according to SCT.

AB - Introduction: Mounting evidence indicates a significant relationship between Sasang constitutional types (SCTs) and metabolic syndrome (MetS), and between metabolic hormones and risk of MetS. However, studies have not yet examined whether the impact of metabolic hormones on MetS differs according to SCT. The aim of this study was to investigate whether the association of adiponectin, ghrelin, leptin with MetS and metabolic components is affected by SCTs. Methods: A total of 2370 subjects (1201 men and 1169 women) who participated in the Korean Genome and Epidemiology Study-Ansan cohort between 2007 and 2008 and completed the health-related questionnaire, anthropometric evaluation, and biochemical measurements were included in the analysis. Each constitutional type was defined using an integrated diagnostic method. Total adiponectin, ghrelin, and leptin levels were determined by enzyme-linked immunosorbent assay or radioimmunoassay. Results: Tae-eum (TE) type had the highest frequency of MetS (29.9%). In multivariate logistic regression analysis adjusted for possible confounders, adiponectin (OR = 0.88, 95% CI: 0.84–0.92; P < 0.0001) and leptin levels (OR = 1.05, 95% CI: 1.01–1.08; P = 0.015) were significantly associated with MetS in TE type, whereas only adiponectin levels were significantly associated with MetS in So-yang type (OR = 0.81, 95% CI: 0.73–0.90; P < 0.0001). Ghrelin levels were not significantly associated with MetS in all SCTs. Conclusions: This population-based study showed different association of adiponectin, ghrelin, and leptin with MetS and its components according to SCT.

KW - Adiponectin

KW - Ghrelin

KW - Leptin

KW - Metabolic syndrome

KW - Sasang constitutional types

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