Abstract
Objective- Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis. F-Fluorodeoxyglucose (FDG) positron emission tomography is a promising imaging technique that can be used to evaluate vascular inflammation. Methods and Results- We measured adiponectin and resistin levels, as well as traditional cardiovascular risk factors, in 60 obese subjects and 60 nonobese controls. In addition, we compared carotid intima-media thickness and target-to-background ratio (TBR) measured using F-fluorodeoxyglucose-positron emission tomography/computed tomography. The mean TBR values were significantly higher in the obese group compared with normal subjects, although their mean carotid intima-media thickness levels were not significantly different. Serum adiponectin levels showed a significant negative correlation with mean TBR values (r=-0.215, P=0.020), whereas resistin levels were positively correlated with mean TBR values (r=0.214, P=0.021). Multiple linear regression analysis showed that mean TBR values were independently associated with body mass index, high-sensitivity C-reactive protein, and resistin levels (R=0.308). Conclusion- Adiponectin and resistin may be useful as biomarkers to reflect vascular inflammation. In particular, resistin levels were independently associated with vascular inflammation even after adjusting for other cardiovascular risk factors.
| Original language | English |
|---|---|
| Pages (from-to) | 944-949 |
| Number of pages | 6 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Apr 1 |
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Keywords
- adiponectin
- inflammation
- positron emission tomography
- resistin
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Association of adiponectin, resistin, and vascular inflammation : Analysis with 18F-fluorodeoxyglucose positron emission tomography. / Choi, Hae Yoon; Kim, Sungeun; Yang, Sae Jeong; Yoo, Hye-Jin; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 31, No. 4, 01.04.2011, p. 944-949.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of adiponectin, resistin, and vascular inflammation
T2 - Analysis with 18F-fluorodeoxyglucose positron emission tomography
AU - Choi, Hae Yoon
AU - Kim, Sungeun
AU - Yang, Sae Jeong
AU - Yoo, Hye-Jin
AU - Seo, Ji A
AU - Kim, Sin Gon
AU - Kim, Nan Hee
AU - Baik, Sei-Hyun
AU - Choi, Dong Seop
AU - Choi, Kyung Mook
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Objective- Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis. F-Fluorodeoxyglucose (FDG) positron emission tomography is a promising imaging technique that can be used to evaluate vascular inflammation. Methods and Results- We measured adiponectin and resistin levels, as well as traditional cardiovascular risk factors, in 60 obese subjects and 60 nonobese controls. In addition, we compared carotid intima-media thickness and target-to-background ratio (TBR) measured using F-fluorodeoxyglucose-positron emission tomography/computed tomography. The mean TBR values were significantly higher in the obese group compared with normal subjects, although their mean carotid intima-media thickness levels were not significantly different. Serum adiponectin levels showed a significant negative correlation with mean TBR values (r=-0.215, P=0.020), whereas resistin levels were positively correlated with mean TBR values (r=0.214, P=0.021). Multiple linear regression analysis showed that mean TBR values were independently associated with body mass index, high-sensitivity C-reactive protein, and resistin levels (R=0.308). Conclusion- Adiponectin and resistin may be useful as biomarkers to reflect vascular inflammation. In particular, resistin levels were independently associated with vascular inflammation even after adjusting for other cardiovascular risk factors.
AB - Objective- Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis. F-Fluorodeoxyglucose (FDG) positron emission tomography is a promising imaging technique that can be used to evaluate vascular inflammation. Methods and Results- We measured adiponectin and resistin levels, as well as traditional cardiovascular risk factors, in 60 obese subjects and 60 nonobese controls. In addition, we compared carotid intima-media thickness and target-to-background ratio (TBR) measured using F-fluorodeoxyglucose-positron emission tomography/computed tomography. The mean TBR values were significantly higher in the obese group compared with normal subjects, although their mean carotid intima-media thickness levels were not significantly different. Serum adiponectin levels showed a significant negative correlation with mean TBR values (r=-0.215, P=0.020), whereas resistin levels were positively correlated with mean TBR values (r=0.214, P=0.021). Multiple linear regression analysis showed that mean TBR values were independently associated with body mass index, high-sensitivity C-reactive protein, and resistin levels (R=0.308). Conclusion- Adiponectin and resistin may be useful as biomarkers to reflect vascular inflammation. In particular, resistin levels were independently associated with vascular inflammation even after adjusting for other cardiovascular risk factors.
KW - adiponectin
KW - inflammation
KW - positron emission tomography
KW - resistin
UR - http://www.scopus.com/inward/record.url?scp=79953744702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953744702&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.110.220673
DO - 10.1161/ATVBAHA.110.220673
M3 - Article
C2 - 21212400
AN - SCOPUS:79953744702
VL - 31
SP - 944
EP - 949
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 4
ER -