Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients

Hyung Jin Yoon, Ho Jun Chin, Ki Young Na, Dong Wan Chae, Suhnggwon Kim, Un Sil Jeon, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Young Joo Kwon, Hyun Chul Kim, Sung Bae Park, Hye Young Kim, Tae Woo Lee, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun Bae, Young Tai ShinKang Wook Lee, Ki Ryang Na, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Wonsuk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Kyo Soon Kim, Won Yong Cho, Hyung Kyu Kim, Sang Kyung Jo, Cha Dae Ryong, Kang Young Sun, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee, Jun Young Do, Jong Won Park, Kyung Woo Yoon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.

Original languageEnglish
Pages (from-to)S38-S43
JournalJournal of Korean medical science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009

Keywords

  • Angiotensin
  • Glomerulonephritis
  • IGA
  • Polymorphism
  • Receptor
  • Single nucleotide
  • Type 2

ASJC Scopus subject areas

  • Medicine(all)

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