Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients

Hyung Jin Yoon, Ho Jun Chin, Ki Young Na, Dong Wan Chae, Suhnggwon Kim, Un Sil Jeon, Woo Kyung Chung, Hyun Hee Lee, Jaeseok Yang, Sejoong Kim, Young-Joo Kwon, Hyun Chul Kim, Sung Bae Park, Hye Young Kim, Tae Woo Lee, Eun Hee Jang, Won Kim, Nam Ho Kim, Woo Kyun Bae, Young Tai ShinKang Wook Lee, Ki Ryang Na, Ki Sung Ahn, Jong Tae Cho, Eun Kyeong Lee, Ki Hyun Kim, Wonsuk An, Seong Eun Kim, Choi Gyu Bog, Seung Jung Kim, Se Ho Chang, Jung Woo Noh, Young Ki Lee, Seong Gyun Kim, Jieun Oh, Young Rim Song, Moon Jae Kim, Seoung Woo Lee, Yeong Hoon Kim, Won Do Park, Kyo Soon Kim, Won Yong Cho, Hyung Kyu Kim, Sang Kyung Jo, Dae-Ryong Cha, Young Sun Kang, Yong Lim Kim, Sun Hee Park, Chan Duck Kim, Dong Ho Yang, Ihm Soo Kwak, Soo Bong Lee, Dong Won Lee, Sang Heon Song, Eun Young Seoung, Su Jin Yoon, Chun Soo Lim, Yoon Kyu Oh, Kook Hwan Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Jin Suk Han, Kyu Beck Lee, Yoon Goo Kim, Jung Eun Lee, Sang Koo Lee, Jun Young Do, Jong Won Park, Kyung Woo Yoon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.

Original languageEnglish
JournalJournal of Korean Medical Science
Volume24
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

IGA Glomerulonephritis
Angiotensin Type 2 Receptor
Immunoglobulins
Alleles
Genes
Creatinine
Medical Informatics
Nephrology
Survival Analysis
Genomics
Serum
Proteinuria
Proportional Hazards Models
Restriction Fragment Length Polymorphisms
Introns
Registries
Disease Progression
Confidence Intervals
Blood Pressure
Kidney

Keywords

  • Angiotensin
  • Glomerulonephritis
  • IGA
  • Polymorphism
  • Receptor
  • Single nucleotide
  • Type 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients. / Yoon, Hyung Jin; Chin, Ho Jun; Na, Ki Young; Chae, Dong Wan; Kim, Suhnggwon; Jeon, Un Sil; Chung, Woo Kyung; Lee, Hyun Hee; Yang, Jaeseok; Kim, Sejoong; Kwon, Young-Joo; Kim, Hyun Chul; Park, Sung Bae; Kim, Hye Young; Lee, Tae Woo; Jang, Eun Hee; Kim, Won; Kim, Nam Ho; Bae, Woo Kyun; Shin, Young Tai; Lee, Kang Wook; Na, Ki Ryang; Ahn, Ki Sung; Cho, Jong Tae; Lee, Eun Kyeong; Kim, Ki Hyun; An, Wonsuk; Kim, Seong Eun; Bog, Choi Gyu; Kim, Seung Jung; Chang, Se Ho; Noh, Jung Woo; Lee, Young Ki; Kim, Seong Gyun; Oh, Jieun; Song, Young Rim; Kim, Moon Jae; Lee, Seoung Woo; Kim, Yeong Hoon; Park, Won Do; Kim, Kyo Soon; Cho, Won Yong; Kim, Hyung Kyu; Jo, Sang Kyung; Cha, Dae-Ryong; Kang, Young Sun; Kim, Yong Lim; Park, Sun Hee; Kim, Chan Duck; Yang, Dong Ho; Kwak, Ihm Soo; Lee, Soo Bong; Lee, Dong Won; Song, Sang Heon; Seoung, Eun Young; Yoon, Su Jin; Lim, Chun Soo; Oh, Yoon Kyu; Oh, Kook Hwan; Joo, Kwon Wook; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Lee, Kyu Beck; Kim, Yoon Goo; Lee, Jung Eun; Lee, Sang Koo; Do, Jun Young; Park, Jong Won; Yoon, Kyung Woo.

In: Journal of Korean Medical Science, Vol. 24, No. SUPPL.1, 01.01.2009.

Research output: Contribution to journalArticle

Yoon, HJ, Chin, HJ, Na, KY, Chae, DW, Kim, S, Jeon, US, Chung, WK, Lee, HH, Yang, J, Kim, S, Kwon, Y-J, Kim, HC, Park, SB, Kim, HY, Lee, TW, Jang, EH, Kim, W, Kim, NH, Bae, WK, Shin, YT, Lee, KW, Na, KR, Ahn, KS, Cho, JT, Lee, EK, Kim, KH, An, W, Kim, SE, Bog, CG, Kim, SJ, Chang, SH, Noh, JW, Lee, YK, Kim, SG, Oh, J, Song, YR, Kim, MJ, Lee, SW, Kim, YH, Park, WD, Kim, KS, Cho, WY, Kim, HK, Jo, SK, Cha, D-R, Kang, YS, Kim, YL, Park, SH, Kim, CD, Yang, DH, Kwak, IS, Lee, SB, Lee, DW, Song, SH, Seoung, EY, Yoon, SJ, Lim, CS, Oh, YK, Oh, KH, Joo, KW, Kim, YS, Ahn, C, Han, JS, Lee, KB, Kim, YG, Lee, JE, Lee, SK, Do, JY, Park, JW & Yoon, KW 2009, 'Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients', Journal of Korean Medical Science, vol. 24, no. SUPPL.1. https://doi.org/10.3346/jkms.2009.24.S1.S38
Yoon, Hyung Jin ; Chin, Ho Jun ; Na, Ki Young ; Chae, Dong Wan ; Kim, Suhnggwon ; Jeon, Un Sil ; Chung, Woo Kyung ; Lee, Hyun Hee ; Yang, Jaeseok ; Kim, Sejoong ; Kwon, Young-Joo ; Kim, Hyun Chul ; Park, Sung Bae ; Kim, Hye Young ; Lee, Tae Woo ; Jang, Eun Hee ; Kim, Won ; Kim, Nam Ho ; Bae, Woo Kyun ; Shin, Young Tai ; Lee, Kang Wook ; Na, Ki Ryang ; Ahn, Ki Sung ; Cho, Jong Tae ; Lee, Eun Kyeong ; Kim, Ki Hyun ; An, Wonsuk ; Kim, Seong Eun ; Bog, Choi Gyu ; Kim, Seung Jung ; Chang, Se Ho ; Noh, Jung Woo ; Lee, Young Ki ; Kim, Seong Gyun ; Oh, Jieun ; Song, Young Rim ; Kim, Moon Jae ; Lee, Seoung Woo ; Kim, Yeong Hoon ; Park, Won Do ; Kim, Kyo Soon ; Cho, Won Yong ; Kim, Hyung Kyu ; Jo, Sang Kyung ; Cha, Dae-Ryong ; Kang, Young Sun ; Kim, Yong Lim ; Park, Sun Hee ; Kim, Chan Duck ; Yang, Dong Ho ; Kwak, Ihm Soo ; Lee, Soo Bong ; Lee, Dong Won ; Song, Sang Heon ; Seoung, Eun Young ; Yoon, Su Jin ; Lim, Chun Soo ; Oh, Yoon Kyu ; Oh, Kook Hwan ; Joo, Kwon Wook ; Kim, Yon Su ; Ahn, Curie ; Han, Jin Suk ; Lee, Kyu Beck ; Kim, Yoon Goo ; Lee, Jung Eun ; Lee, Sang Koo ; Do, Jun Young ; Park, Jong Won ; Yoon, Kyung Woo. / Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients. In: Journal of Korean Medical Science. 2009 ; Vol. 24, No. SUPPL.1.
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abstract = "We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50{\%} increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4{\%} vs. 3.9{\%}, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95{\%} confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.",
keywords = "Angiotensin, Glomerulonephritis, IGA, Polymorphism, Receptor, Single nucleotide, Type 2",
author = "Yoon, {Hyung Jin} and Chin, {Ho Jun} and Na, {Ki Young} and Chae, {Dong Wan} and Suhnggwon Kim and Jeon, {Un Sil} and Chung, {Woo Kyung} and Lee, {Hyun Hee} and Jaeseok Yang and Sejoong Kim and Young-Joo Kwon and Kim, {Hyun Chul} and Park, {Sung Bae} and Kim, {Hye Young} and Lee, {Tae Woo} and Jang, {Eun Hee} and Won Kim and Kim, {Nam Ho} and Bae, {Woo Kyun} and Shin, {Young Tai} and Lee, {Kang Wook} and Na, {Ki Ryang} and Ahn, {Ki Sung} and Cho, {Jong Tae} and Lee, {Eun Kyeong} and Kim, {Ki Hyun} and Wonsuk An and Kim, {Seong Eun} and Bog, {Choi Gyu} and Kim, {Seung Jung} and Chang, {Se Ho} and Noh, {Jung Woo} and Lee, {Young Ki} and Kim, {Seong Gyun} and Jieun Oh and Song, {Young Rim} and Kim, {Moon Jae} and Lee, {Seoung Woo} and Kim, {Yeong Hoon} and Park, {Won Do} and Kim, {Kyo Soon} and Cho, {Won Yong} and Kim, {Hyung Kyu} and Jo, {Sang Kyung} and Dae-Ryong Cha and Kang, {Young Sun} and Kim, {Yong Lim} and Park, {Sun Hee} and Kim, {Chan Duck} and Yang, {Dong Ho} and Kwak, {Ihm Soo} and Lee, {Soo Bong} and Lee, {Dong Won} and Song, {Sang Heon} and Seoung, {Eun Young} and Yoon, {Su Jin} and Lim, {Chun Soo} and Oh, {Yoon Kyu} and Oh, {Kook Hwan} and Joo, {Kwon Wook} and Kim, {Yon Su} and Curie Ahn and Han, {Jin Suk} and Lee, {Kyu Beck} and Kim, {Yoon Goo} and Lee, {Jung Eun} and Lee, {Sang Koo} and Do, {Jun Young} and Park, {Jong Won} and Yoon, {Kyung Woo}",
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T1 - Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients

AU - Yoon, Hyung Jin

AU - Chin, Ho Jun

AU - Na, Ki Young

AU - Chae, Dong Wan

AU - Kim, Suhnggwon

AU - Jeon, Un Sil

AU - Chung, Woo Kyung

AU - Lee, Hyun Hee

AU - Yang, Jaeseok

AU - Kim, Sejoong

AU - Kwon, Young-Joo

AU - Kim, Hyun Chul

AU - Park, Sung Bae

AU - Kim, Hye Young

AU - Lee, Tae Woo

AU - Jang, Eun Hee

AU - Kim, Won

AU - Kim, Nam Ho

AU - Bae, Woo Kyun

AU - Shin, Young Tai

AU - Lee, Kang Wook

AU - Na, Ki Ryang

AU - Ahn, Ki Sung

AU - Cho, Jong Tae

AU - Lee, Eun Kyeong

AU - Kim, Ki Hyun

AU - An, Wonsuk

AU - Kim, Seong Eun

AU - Bog, Choi Gyu

AU - Kim, Seung Jung

AU - Chang, Se Ho

AU - Noh, Jung Woo

AU - Lee, Young Ki

AU - Kim, Seong Gyun

AU - Oh, Jieun

AU - Song, Young Rim

AU - Kim, Moon Jae

AU - Lee, Seoung Woo

AU - Kim, Yeong Hoon

AU - Park, Won Do

AU - Kim, Kyo Soon

AU - Cho, Won Yong

AU - Kim, Hyung Kyu

AU - Jo, Sang Kyung

AU - Cha, Dae-Ryong

AU - Kang, Young Sun

AU - Kim, Yong Lim

AU - Park, Sun Hee

AU - Kim, Chan Duck

AU - Yang, Dong Ho

AU - Kwak, Ihm Soo

AU - Lee, Soo Bong

AU - Lee, Dong Won

AU - Song, Sang Heon

AU - Seoung, Eun Young

AU - Yoon, Su Jin

AU - Lim, Chun Soo

AU - Oh, Yoon Kyu

AU - Oh, Kook Hwan

AU - Joo, Kwon Wook

AU - Kim, Yon Su

AU - Ahn, Curie

AU - Han, Jin Suk

AU - Lee, Kyu Beck

AU - Kim, Yoon Goo

AU - Lee, Jung Eun

AU - Lee, Sang Koo

AU - Do, Jun Young

AU - Park, Jong Won

AU - Yoon, Kyung Woo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.

AB - We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.

KW - Angiotensin

KW - Glomerulonephritis

KW - IGA

KW - Polymorphism

KW - Receptor

KW - Single nucleotide

KW - Type 2

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