Association of apo E polymorphism with variations in lipid and small dense LDL in Koreans with a low fat intake

Min-Jeong Shin, Eun Young Cho, Hyun Young Park, Hong Keun Cho, Jong Ho Leea, Yangsoo Jang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated whether apo E polymorphism contributes to the variations in blood lipid profile, apolipoprotein B and small dense LDL in 92 clinically healthy Korean subjects who traditionally consume a low fat and low cholesterol diet (40 males, 52 females, aged 24-60). Body weight, height, waist and hip circumference were measured. Body mass index (BMI) and waist to hip ratio (WHR) were calculated. Dietary intake was assessed by using a semi-quantitative Food Frequency Questionnaire. Alleles ε3, ε2 and ε4 showed relative frequencies of 72.8%, 7.6%, and 19.6%, respectively, in the subjects. In order to estimate the independent effects of alleles ε2 and ε4, as compared with ε3 homozygosity, on lipid and apolipoprotein parameters, multiple linear regression was performed after adjustment for confounding variables such as age, gender, BMI, WHR, smoking and alcohol consumption. Apo E polymorphism was associated with variations in the serum concentrations of LDL-cholesterol, apolipoprotein B and concentration of LDLIII (d 1.044 - 1.063 g/ml), and was higher in the allele ε4 than ε3 homozygosity. Moreover, the allele ε4 significantly increased the concentration of LDLIII even after adjustment for the serum concentration of triacylglycerol. The allele ε2 did not show any significant effects on lipid or apolipoprotein concentrations. Our results showed that the apo E4 isoform was related to higher levels of LDL-cholesterol and small dense LDL in Koreans who are exposed to a low fat, carbohydrate rich diet.

Original languageEnglish
Pages (from-to)1369-1378
Number of pages10
JournalNutrition Research
Volume23
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1
Externally publishedYes

Fingerprint

Apolipoproteins E
Fats
Alleles
Lipids
Waist-Hip Ratio
Apolipoproteins
Apolipoproteins B
LDL Cholesterol
Body Mass Index
Apolipoprotein E4
Fat-Restricted Diet
Body Height
Confounding Factors (Epidemiology)
Waist Circumference
Serum
Alcohol Drinking
Hip
Linear Models
Healthy Volunteers
Protein Isoforms

Keywords

  • Apolipoprotein E
  • LDL-cholesterol
  • Polymorphism
  • Small dense LDL

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of apo E polymorphism with variations in lipid and small dense LDL in Koreans with a low fat intake. / Shin, Min-Jeong; Cho, Eun Young; Park, Hyun Young; Cho, Hong Keun; Leea, Jong Ho; Jang, Yangsoo.

In: Nutrition Research, Vol. 23, No. 10, 01.10.2003, p. 1369-1378.

Research output: Contribution to journalArticle

Shin, Min-Jeong ; Cho, Eun Young ; Park, Hyun Young ; Cho, Hong Keun ; Leea, Jong Ho ; Jang, Yangsoo. / Association of apo E polymorphism with variations in lipid and small dense LDL in Koreans with a low fat intake. In: Nutrition Research. 2003 ; Vol. 23, No. 10. pp. 1369-1378.
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