Association of apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population

Chang Hee Jung, Jenie Yoonoo Hwang, Mi Seon Shin, Ji Hee Yu, Eun Hee Kim, Sung Jin Bae, Dong Hyun Yang, Joon Won Kang, Joong Yeol Park, Hong Kyu Kim, Woo Je Lee

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Abstract

Despite the noninvasiveness and accuracy of multidetector computed tomography (MDCT), its use as a routine screening tool for occult coronary atherosclerosis is unclear. We investigated whether the ratio of apolipoprotein B (apoB) toapolipoprotein A1 (apoA1), an indicator of the balance between atherogenic and atheroprotective cholesterol transport could predict occult coronary atherosclerosis detected by MDCT. We collected the data of 1,401 subjects (877 men and 5 4 women) who participated in a routine health screening examination of Asan Medical Center. Significant coronary arterystenosis defined as > 50% stenosis was detected in 114 subjects (8.1%). An increase in apoB/A1 quartiles was associatedwith increased percentages of subjects with significant coronary stenosis and noncalcified plaques (NCAP). After adjustment for confounding variables, each 0.1 increase in serum apoB/A1 was significantly associated with increased odds ratios (ORs) for coronary stenosis and NCAP of 1.23 and 1.18, respectively. The optimal apoB/A1 ratio cut off value for MDCT detection of significant coronary stenosis was 0.58, which had a sensitivity of 70.2% and a specificity of 48.2% (area under the curve, 0.61; 95% CI, 0.58- 0.63, P < 0.001). Our results indicate that apoB/A1 ratio is a good indicator of occult coronary atherosclerosis detected by coronary MDCT.

Original languageEnglish
Pages (from-to)709-716
Number of pages8
JournalJournal of Korean medical science
Volume28
Issue number5
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

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Keywords

  • Apolipoproteins A1
  • Apolipoproteins B
  • Coronary disease
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Medicine(all)

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