Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations: Meta-analysis including Korean samples

Sangmee A. Jo, Kyungsook Ahn, Eunkyung Kim, Hwa Su Kim, Inho Jo, Doh Kwan Kim, Changsoo Han, Moon Ho Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: β-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer's disease (AD) from its key role in β-amyloid generation. Previous genetic association studies of BACE1 gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of BACE1 (rs638405, Val262) is associated with a risk for late-onset AD. Methods: We genotyped a synonymous C/G polymorphism of BACE1 located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. Results: The allele and genotype frequencies of BACE1 polymorphism were not significantly different between cases and controls (p > 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE-ε4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319-3.018). Conclusion: These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE ε4 allele.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

Fingerprint

Meta-Analysis
Alzheimer Disease
Apolipoprotein E4
Exons
Population
Genes
Genotype
Alleles
Amyloid beta-Protein Precursor
Genetic Association Studies
Amyloid
Gene Frequency
Single Nucleotide Polymorphism
Enzymes

Keywords

  • β-Amyloid
  • β-Site amyloid precursor protein cleaving enzyme
  • Alzheimer's disease
  • Apolipoprotein E

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations : Meta-analysis including Korean samples. / Jo, Sangmee A.; Ahn, Kyungsook; Kim, Eunkyung; Kim, Hwa Su; Jo, Inho; Kim, Doh Kwan; Han, Changsoo; Park, Moon Ho.

In: Dementia and Geriatric Cognitive Disorders, Vol. 25, No. 2, 01.02.2008, p. 165-169.

Research output: Contribution to journalArticle

Jo, Sangmee A. ; Ahn, Kyungsook ; Kim, Eunkyung ; Kim, Hwa Su ; Jo, Inho ; Kim, Doh Kwan ; Han, Changsoo ; Park, Moon Ho. / Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations : Meta-analysis including Korean samples. In: Dementia and Geriatric Cognitive Disorders. 2008 ; Vol. 25, No. 2. pp. 165-169.
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AB - Background: β-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer's disease (AD) from its key role in β-amyloid generation. Previous genetic association studies of BACE1 gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of BACE1 (rs638405, Val262) is associated with a risk for late-onset AD. Methods: We genotyped a synonymous C/G polymorphism of BACE1 located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. Results: The allele and genotype frequencies of BACE1 polymorphism were not significantly different between cases and controls (p > 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE-ε4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319-3.018). Conclusion: These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE ε4 allele.

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