Abstract
Considerable evidence suggests a crucial role for the epigenetic regulation of brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BDNF DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BDNF promoter region and WM integrity in MDD. Sixty patients with MDD and 53 healthy controls underwent T1-weighted structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. BDNF DNA methylation at 4 CpG sites of the promoter region was also measured. As compared to healthy controls, the MDD group demonstrated reduced fractional anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and PCR), genu of the corpus callosum, and the bilateral posterior thalamic radiations. We observed a significant inverse correlation between the DNA methylation of the BDNF promoter region and the FA of the right ACR in MDD patients. Our findings demonstrate a relationship between methylation of the BDNF promoter region and the integrity of the ACR, a key structural component of the emotional and cognitive control network involved in the pathophysiology of MDD. This correlation suggests that BDNF DNA methylation may contribute to structural WM changes in MDD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 74-80 |
| Number of pages | 7 |
| Journal | Journal of Affective Disorders |
| Volume | 172 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression. / Choi, Sunyoung; Han, Kyu Man; Won, Eunsoo; Yoon, Bongjune; Lee, Min-Soo; Ham, Byung-Joo.
In: Journal of Affective Disorders, Vol. 172, 01.01.2015, p. 74-80.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression
AU - Choi, Sunyoung
AU - Han, Kyu Man
AU - Won, Eunsoo
AU - Yoon, Bongjune
AU - Lee, Min-Soo
AU - Ham, Byung-Joo
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Considerable evidence suggests a crucial role for the epigenetic regulation of brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BDNF DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BDNF promoter region and WM integrity in MDD. Sixty patients with MDD and 53 healthy controls underwent T1-weighted structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. BDNF DNA methylation at 4 CpG sites of the promoter region was also measured. As compared to healthy controls, the MDD group demonstrated reduced fractional anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and PCR), genu of the corpus callosum, and the bilateral posterior thalamic radiations. We observed a significant inverse correlation between the DNA methylation of the BDNF promoter region and the FA of the right ACR in MDD patients. Our findings demonstrate a relationship between methylation of the BDNF promoter region and the integrity of the ACR, a key structural component of the emotional and cognitive control network involved in the pathophysiology of MDD. This correlation suggests that BDNF DNA methylation may contribute to structural WM changes in MDD patients.
AB - Considerable evidence suggests a crucial role for the epigenetic regulation of brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BDNF DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BDNF promoter region and WM integrity in MDD. Sixty patients with MDD and 53 healthy controls underwent T1-weighted structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. BDNF DNA methylation at 4 CpG sites of the promoter region was also measured. As compared to healthy controls, the MDD group demonstrated reduced fractional anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and PCR), genu of the corpus callosum, and the bilateral posterior thalamic radiations. We observed a significant inverse correlation between the DNA methylation of the BDNF promoter region and the FA of the right ACR in MDD patients. Our findings demonstrate a relationship between methylation of the BDNF promoter region and the integrity of the ACR, a key structural component of the emotional and cognitive control network involved in the pathophysiology of MDD. This correlation suggests that BDNF DNA methylation may contribute to structural WM changes in MDD patients.
KW - Anterior corona radiata
KW - Brain-derived neurotrophic factor (BDNF)
KW - Diffusion tensor imaging (DTI)
KW - DNA methylation
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=84908432764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908432764&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2014.09.042
DO - 10.1016/j.jad.2014.09.042
M3 - Article
VL - 172
SP - 74
EP - 80
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -