Abstract
Objective Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population. Methods We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls. Results Genotype frequencies of both rs723672 and rs1051375 SNPs were significantly different in patients and controls (p=0.0462 and 1.732E-14, respectively). Dominant, recessive, and allele models showed significant differences between patients and controls with respect to the rs1051375 SNP (p=1.72E-11, 4.17E-10, 4.95E-16, respectively). Conclusion Our results suggested that CACNA1C SNPs rs723672 and rs1051375 were associated with bipolar disorder in the Korean population. In addition, our results highlighted the importance of CACNA1C in determining susceptibility to bipolar disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 453-457 |
| Number of pages | 5 |
| Journal | Psychiatry Investigation |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Jul 1 |
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Keywords
- CACNA1C
- Disorder
- Polymorphism
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Association of CACNA1C variants with bipolar disorder in the Korean population. / Kim, Soojin; Cho, Chul Hyun; Geum, Dongho; Lee, Heon-Jeong.
In: Psychiatry Investigation, Vol. 13, No. 4, 01.07.2016, p. 453-457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of CACNA1C variants with bipolar disorder in the Korean population
AU - Kim, Soojin
AU - Cho, Chul Hyun
AU - Geum, Dongho
AU - Lee, Heon-Jeong
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population. Methods We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls. Results Genotype frequencies of both rs723672 and rs1051375 SNPs were significantly different in patients and controls (p=0.0462 and 1.732E-14, respectively). Dominant, recessive, and allele models showed significant differences between patients and controls with respect to the rs1051375 SNP (p=1.72E-11, 4.17E-10, 4.95E-16, respectively). Conclusion Our results suggested that CACNA1C SNPs rs723672 and rs1051375 were associated with bipolar disorder in the Korean population. In addition, our results highlighted the importance of CACNA1C in determining susceptibility to bipolar disorder.
AB - Objective Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population. Methods We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls. Results Genotype frequencies of both rs723672 and rs1051375 SNPs were significantly different in patients and controls (p=0.0462 and 1.732E-14, respectively). Dominant, recessive, and allele models showed significant differences between patients and controls with respect to the rs1051375 SNP (p=1.72E-11, 4.17E-10, 4.95E-16, respectively). Conclusion Our results suggested that CACNA1C SNPs rs723672 and rs1051375 were associated with bipolar disorder in the Korean population. In addition, our results highlighted the importance of CACNA1C in determining susceptibility to bipolar disorder.
KW - CACNA1C
KW - Disorder
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84982938374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982938374&partnerID=8YFLogxK
U2 - 10.4306/pi.2016.13.4.453
DO - 10.4306/pi.2016.13.4.453
M3 - Article
AN - SCOPUS:84982938374
VL - 13
SP - 453
EP - 457
JO - Psychiatry Investigation
JF - Psychiatry Investigation
SN - 1738-3684
IS - 4
ER -