Association of CD57+ natural killer cells with better overall survival in DLBCL patients

Jeong Hyeon Lee, Yoon Jin Kwak, Chul Hwan Kim, Insun Kim

Research output: Contribution to journalArticle

Abstract

Background: Malignant tumor cells may evoke the innate and adaptive immune systems. Various immune cells are involved in this immune reaction, and tumor infiltrating lymphocytes, macrophages, natural killer (NK) cells are associated with patient prognosis for solid tumors. Methods: Seventy-eight patients who were diagnosed with diffuse large B cell lymphoma (DLBCL) between 2001 and 2009 were selected. CD57+ NK cells, CD68+ tumor associated macrophages (TAMs), and CD4+ and CD8+ T cells were evaluated in tissue sections using immunohistochemical staining and compared with clinical parameters including age, gender, performance status, clinical stage, serum lactic dehydrogenase level, number of extranodal sites, international prognostic index score, chemotherapy response, and survival. Results: Patients with high numbers of CD57+ NK cells had a significantly higher overall survival rate than patients with low numbers of CD57+ NK cells. However, no significant difference was observed between the number of CD57+ NK cells and other prognostic parameters. The number of CD68+ TAMs and CD4+ or CD8+ T cells was not significantly correlated with prognostic factors in patients with DLBCL. Conclusions: An evaluation of tumor infiltrating CD57+ NK cells is recommended as a prognostic indicator in patients with DLBCL.

Original languageEnglish
Pages (from-to)361-370
Number of pages10
JournalKorean Journal of Pathology
Volume45
Issue number4
DOIs
Publication statusPublished - 2011 Sep 26

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Lymphoma, Large B-Cell, Diffuse
Natural Killer Cells
Survival
Macrophages
Neoplasms
T-Lymphocytes
Tumor-Infiltrating Lymphocytes
Immune System
Oxidoreductases
Milk
Survival Rate
Staining and Labeling
Drug Therapy
Serum

Keywords

  • CD57
  • Killer cells
  • Large B-cell diffuse
  • Lymphoma
  • Natural
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Association of CD57+ natural killer cells with better overall survival in DLBCL patients. / Lee, Jeong Hyeon; Kwak, Yoon Jin; Kim, Chul Hwan; Kim, Insun.

In: Korean Journal of Pathology, Vol. 45, No. 4, 26.09.2011, p. 361-370.

Research output: Contribution to journalArticle

Lee, Jeong Hyeon ; Kwak, Yoon Jin ; Kim, Chul Hwan ; Kim, Insun. / Association of CD57+ natural killer cells with better overall survival in DLBCL patients. In: Korean Journal of Pathology. 2011 ; Vol. 45, No. 4. pp. 361-370.
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