Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes

Hye-Jin Yoo, Soon Y. Hwang, Ho C. Hong, Hae Y. Choi, Sae J. Yang, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Dong S. Choi, Sei-Hyun Baik

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: Adipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited.Methods: We enrolled 60 people with type 2 diabetes, with or without carotid plaque, and 30 participants with normal glucose tolerance. We measured serum omentin-1, high-sensitivity C-reactive protein (hsCRP) levels, and the homeostasis model assessment of insulin resistance (HOMA-IR), as well as other cardiovascular risk factors. Vascular health was assessed by brachial ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT).Results: Serum omentin-1 levels were significantly decreased in type 2 diabetes patients compared to normal glucose controls and was further reduced in type 2 diabetes patients with carotid plaque compared to those without carotid plaque. Multiple stepwise regression analysis showed that age, systolic blood pressure, history of use of statins, angiotensin receptor blockers or angiotensin-converting enzyme inhibitors, and serum omentin-1 level were independent factors determining baPWV in people with type 2 diabetes (r2 = 0.637). Furthermore, in multivariate logistic regression analysis, circulating omentin-1 level was an independent decisive factor for the presence of carotid plaque in type 2 diabetes patients, even after adjusting for age, gender, body mass index, systolic blood pressure, fasting blood glucose, low density lipoprotein cholesterol, and history of smoking and medication (odds ratio, 0.621; 95% confidence interval, 0.420-0.919; P = 0.017).Conclusions: Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.

Original languageEnglish
Article number103
JournalCardiovascular Diabetology
Volume10
DOIs
Publication statusPublished - 2011 Nov 22

Fingerprint

Vascular Stiffness
Type 2 Diabetes Mellitus
Adipokines
Blood Pressure
Pulse Wave Analysis
Ankle
Blood Vessels
Arm
Serum
Regression Analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Glucose
Carotid Intima-Media Thickness
Angiotensin Receptor Antagonists
Health
Angiotensin-Converting Enzyme Inhibitors
C-Reactive Protein
LDL Cholesterol
Insulin Resistance
Blood Glucose

Keywords

  • Carotid intima media thickness
  • Omentin-1
  • Pulse wave velocity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes. / Yoo, Hye-Jin; Hwang, Soon Y.; Hong, Ho C.; Choi, Hae Y.; Yang, Sae J.; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Choi, Kyung Mook; Choi, Dong S.; Baik, Sei-Hyun.

In: Cardiovascular Diabetology, Vol. 10, 103, 22.11.2011.

Research output: Contribution to journalArticle

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AU - Yoo, Hye-Jin

AU - Hwang, Soon Y.

AU - Hong, Ho C.

AU - Choi, Hae Y.

AU - Yang, Sae J.

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Choi, Kyung Mook

AU - Choi, Dong S.

AU - Baik, Sei-Hyun

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AB - Background: Adipokines contribute directly to the atherosclerotic process, connecting metabolic disorders such as obesity and diabetes to cardiovascular disease. Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited.Methods: We enrolled 60 people with type 2 diabetes, with or without carotid plaque, and 30 participants with normal glucose tolerance. We measured serum omentin-1, high-sensitivity C-reactive protein (hsCRP) levels, and the homeostasis model assessment of insulin resistance (HOMA-IR), as well as other cardiovascular risk factors. Vascular health was assessed by brachial ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT).Results: Serum omentin-1 levels were significantly decreased in type 2 diabetes patients compared to normal glucose controls and was further reduced in type 2 diabetes patients with carotid plaque compared to those without carotid plaque. Multiple stepwise regression analysis showed that age, systolic blood pressure, history of use of statins, angiotensin receptor blockers or angiotensin-converting enzyme inhibitors, and serum omentin-1 level were independent factors determining baPWV in people with type 2 diabetes (r2 = 0.637). Furthermore, in multivariate logistic regression analysis, circulating omentin-1 level was an independent decisive factor for the presence of carotid plaque in type 2 diabetes patients, even after adjusting for age, gender, body mass index, systolic blood pressure, fasting blood glucose, low density lipoprotein cholesterol, and history of smoking and medication (odds ratio, 0.621; 95% confidence interval, 0.420-0.919; P = 0.017).Conclusions: Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.

KW - Carotid intima media thickness

KW - Omentin-1

KW - Pulse wave velocity

KW - Type 2 diabetes

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