Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.

Jong Cheol Jeong, Young Hwan Hwang, Hyosang Kim, Han Ro, Hayne Cho Park, Yoon Jung Kim, Myung-Gyu Kim, Jongwon Ha, Myoung Hee Park, Dong Wan Chae, Curie Ahn, Jaeseok Yang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. We investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes. Seven single-nucleotide polymorphisms (SNPs) in C5 (rs12237774, rs2159776, rs17611, rs25681, rs2241004, rs10985126 and rs10818500) and one SNP (rs10404456) in the C5aR gene were genotyped in 191 recipient-donor pairs. The association of the polymorphisms with allograft outcomes was determined. Three C5 SNPs (rs2159776, rs17611 and rs25681) in recipients had a tendency toward a reduced glomerular filtration rate at 1 year after transplantation. There were four haplotypes in the H2 linkage disequilibrium block, which was formed by four SNPs (rs2159776, rs17611, rs25681 and rs2241004). The GGCG haplotype in both recipients and donors was associated with lower glomerular filtration rate at 1 year (60.9 ± 15.9 versus 66.4 ± 15.5 mL/min/1.73 m(2), P = 0.020; 60.6 ± 15.3 versus 66.2 ± 15.8 mL/min/1.73 m(2), P = 0.017). The association was sustained over 7 years after transplantation (P = 0.015 in recipients; P = 0.039 in donors). The presence of the GGCG haplotype in recipients was associated with poorer graft survival (logrank test, P = 0.024). However, C5 polymorphisms were not correlated with serum C5 level. C5aR polymorphism had no significant impact on the allograft outcomes. The GGCG haplotype of C5 in both recipients and donors was associated with lower renal allograft function.

Original languageEnglish
Pages (from-to)3378-3385
Number of pages8
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume26
Issue number10
Publication statusPublished - 2011 Oct 1
Externally publishedYes

Fingerprint

Complement C5
Genetic Polymorphisms
Korea
Allografts
Kidney
Haplotypes
Single Nucleotide Polymorphism
Transplantation
Glomerular Filtration Rate
Complement Membrane Attack Complex
Linkage Disequilibrium
Graft Survival
Chemotaxis
Reperfusion Injury

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea. / Jeong, Jong Cheol; Hwang, Young Hwan; Kim, Hyosang; Ro, Han; Park, Hayne Cho; Kim, Yoon Jung; Kim, Myung-Gyu; Ha, Jongwon; Park, Myoung Hee; Chae, Dong Wan; Ahn, Curie; Yang, Jaeseok.

In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 26, No. 10, 01.10.2011, p. 3378-3385.

Research output: Contribution to journalArticle

Jeong, Jong Cheol ; Hwang, Young Hwan ; Kim, Hyosang ; Ro, Han ; Park, Hayne Cho ; Kim, Yoon Jung ; Kim, Myung-Gyu ; Ha, Jongwon ; Park, Myoung Hee ; Chae, Dong Wan ; Ahn, Curie ; Yang, Jaeseok. / Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea. In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 ; Vol. 26, No. 10. pp. 3378-3385.
@article{959cd6da3da240c391b438b74f8dcea3,
title = "Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.",
abstract = "Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. We investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes. Seven single-nucleotide polymorphisms (SNPs) in C5 (rs12237774, rs2159776, rs17611, rs25681, rs2241004, rs10985126 and rs10818500) and one SNP (rs10404456) in the C5aR gene were genotyped in 191 recipient-donor pairs. The association of the polymorphisms with allograft outcomes was determined. Three C5 SNPs (rs2159776, rs17611 and rs25681) in recipients had a tendency toward a reduced glomerular filtration rate at 1 year after transplantation. There were four haplotypes in the H2 linkage disequilibrium block, which was formed by four SNPs (rs2159776, rs17611, rs25681 and rs2241004). The GGCG haplotype in both recipients and donors was associated with lower glomerular filtration rate at 1 year (60.9 ± 15.9 versus 66.4 ± 15.5 mL/min/1.73 m(2), P = 0.020; 60.6 ± 15.3 versus 66.2 ± 15.8 mL/min/1.73 m(2), P = 0.017). The association was sustained over 7 years after transplantation (P = 0.015 in recipients; P = 0.039 in donors). The presence of the GGCG haplotype in recipients was associated with poorer graft survival (logrank test, P = 0.024). However, C5 polymorphisms were not correlated with serum C5 level. C5aR polymorphism had no significant impact on the allograft outcomes. The GGCG haplotype of C5 in both recipients and donors was associated with lower renal allograft function.",
author = "Jeong, {Jong Cheol} and Hwang, {Young Hwan} and Hyosang Kim and Han Ro and Park, {Hayne Cho} and Kim, {Yoon Jung} and Myung-Gyu Kim and Jongwon Ha and Park, {Myoung Hee} and Chae, {Dong Wan} and Curie Ahn and Jaeseok Yang",
year = "2011",
month = "10",
day = "1",
language = "English",
volume = "26",
pages = "3378--3385",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.

AU - Jeong, Jong Cheol

AU - Hwang, Young Hwan

AU - Kim, Hyosang

AU - Ro, Han

AU - Park, Hayne Cho

AU - Kim, Yoon Jung

AU - Kim, Myung-Gyu

AU - Ha, Jongwon

AU - Park, Myoung Hee

AU - Chae, Dong Wan

AU - Ahn, Curie

AU - Yang, Jaeseok

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. We investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes. Seven single-nucleotide polymorphisms (SNPs) in C5 (rs12237774, rs2159776, rs17611, rs25681, rs2241004, rs10985126 and rs10818500) and one SNP (rs10404456) in the C5aR gene were genotyped in 191 recipient-donor pairs. The association of the polymorphisms with allograft outcomes was determined. Three C5 SNPs (rs2159776, rs17611 and rs25681) in recipients had a tendency toward a reduced glomerular filtration rate at 1 year after transplantation. There were four haplotypes in the H2 linkage disequilibrium block, which was formed by four SNPs (rs2159776, rs17611, rs25681 and rs2241004). The GGCG haplotype in both recipients and donors was associated with lower glomerular filtration rate at 1 year (60.9 ± 15.9 versus 66.4 ± 15.5 mL/min/1.73 m(2), P = 0.020; 60.6 ± 15.3 versus 66.2 ± 15.8 mL/min/1.73 m(2), P = 0.017). The association was sustained over 7 years after transplantation (P = 0.015 in recipients; P = 0.039 in donors). The presence of the GGCG haplotype in recipients was associated with poorer graft survival (logrank test, P = 0.024). However, C5 polymorphisms were not correlated with serum C5 level. C5aR polymorphism had no significant impact on the allograft outcomes. The GGCG haplotype of C5 in both recipients and donors was associated with lower renal allograft function.

AB - Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. We investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes. Seven single-nucleotide polymorphisms (SNPs) in C5 (rs12237774, rs2159776, rs17611, rs25681, rs2241004, rs10985126 and rs10818500) and one SNP (rs10404456) in the C5aR gene were genotyped in 191 recipient-donor pairs. The association of the polymorphisms with allograft outcomes was determined. Three C5 SNPs (rs2159776, rs17611 and rs25681) in recipients had a tendency toward a reduced glomerular filtration rate at 1 year after transplantation. There were four haplotypes in the H2 linkage disequilibrium block, which was formed by four SNPs (rs2159776, rs17611, rs25681 and rs2241004). The GGCG haplotype in both recipients and donors was associated with lower glomerular filtration rate at 1 year (60.9 ± 15.9 versus 66.4 ± 15.5 mL/min/1.73 m(2), P = 0.020; 60.6 ± 15.3 versus 66.2 ± 15.8 mL/min/1.73 m(2), P = 0.017). The association was sustained over 7 years after transplantation (P = 0.015 in recipients; P = 0.039 in donors). The presence of the GGCG haplotype in recipients was associated with poorer graft survival (logrank test, P = 0.024). However, C5 polymorphisms were not correlated with serum C5 level. C5aR polymorphism had no significant impact on the allograft outcomes. The GGCG haplotype of C5 in both recipients and donors was associated with lower renal allograft function.

UR - http://www.scopus.com/inward/record.url?scp=84858750666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858750666&partnerID=8YFLogxK

M3 - Article

C2 - 21393613

AN - SCOPUS:84858750666

VL - 26

SP - 3378

EP - 3385

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 10

ER -