TY - JOUR
T1 - Association of coronary artery calcification with obstructive sleep apnea and obesity in middle-aged men
AU - Kim, S. H.
AU - Cho, G. Y.
AU - Baik, I.
AU - Kim, J.
AU - Kim, S. J.
AU - Lee, J. B.
AU - Lim, H. E.
AU - Lim, S. Y.
AU - Park, J.
AU - Shin, C.
N1 - Funding Information:
This study was supported by grants (2004-347-6111-213 and 2005-347-2400-2440-215) from the Korean Centers for Disease Control and Prevention.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Background and aims: Obstructive sleep apnea (OSA) and obesity are closely associated, and both have been reported to increase the risk of coronary heart disease. Although obesity is known to be associated with coronary artery calcification (CAC), there is limited information on whether OSA is associated with CAC independent of obesity. Methods and results: A cross-sectional study examined the association between OSA and CAC among 258 healthy men, ages 40-49 years old, randomly selected from a population-based cohort. All individuals underwent overnight polysomnography and electron-beam computed tomography to measure their apnea-hypopnea index (AHI) and degree of CAC. A logistic regression model including potential cardiovascular risk factors excluding body mass index (BMI) showed that the presence of CAC was significantly greater in the fourth quartile versus the first quartile of AHI severity (odds ratio [OR] 2.21, 95% confidence interval [CI] 1.01-4.86). A multivariate linear regression model excluding BMI also showed that AHI was significantly associated with CAC (P=0.004). However, this association was no longer significant after adjusting for BMI. Conclusions: In our cross-sectional study, even though both OSA and obesity were positively associated with the presence and extent of CAC, only obesity remained a significant independent contributor after an adjustment for potential cardiovascular risk factors, irrespective of OSA.
AB - Background and aims: Obstructive sleep apnea (OSA) and obesity are closely associated, and both have been reported to increase the risk of coronary heart disease. Although obesity is known to be associated with coronary artery calcification (CAC), there is limited information on whether OSA is associated with CAC independent of obesity. Methods and results: A cross-sectional study examined the association between OSA and CAC among 258 healthy men, ages 40-49 years old, randomly selected from a population-based cohort. All individuals underwent overnight polysomnography and electron-beam computed tomography to measure their apnea-hypopnea index (AHI) and degree of CAC. A logistic regression model including potential cardiovascular risk factors excluding body mass index (BMI) showed that the presence of CAC was significantly greater in the fourth quartile versus the first quartile of AHI severity (odds ratio [OR] 2.21, 95% confidence interval [CI] 1.01-4.86). A multivariate linear regression model excluding BMI also showed that AHI was significantly associated with CAC (P=0.004). However, this association was no longer significant after adjusting for BMI. Conclusions: In our cross-sectional study, even though both OSA and obesity were positively associated with the presence and extent of CAC, only obesity remained a significant independent contributor after an adjustment for potential cardiovascular risk factors, irrespective of OSA.
KW - Atherosclerosis
KW - Calcium
KW - Coronary artery
KW - Obesity
KW - Obstructive sleep apnea
UR - http://www.scopus.com/inward/record.url?scp=77956776874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956776874&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2009.05.011
DO - 10.1016/j.numecd.2009.05.011
M3 - Article
C2 - 19699072
AN - SCOPUS:77956776874
VL - 20
SP - 575
EP - 582
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 8
ER -
