Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry

Dong Jin Park, Ji Hyoun Kang, Kyung Eun Lee, Seong Wook Kang, Seung Ki Kwok, Seong Kyu Kim, Jung Yoon Choe, Hyoun Ah Kim, Yoon Kyoung Sung, Kichul Shin, Sang Il Lee, Chang Hoon Lee, Sungjae Choi, Shin Seok Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients.

METHODS: In this study, 505 consecutive SLE patients were enrolled from the Korean Lupus Network registry. Demographic variables, clinical manifestations, laboratory findings, physician global assessment, and SLEDAI-2000 and SLICC damage index were recorded at enrolment. Patients were identified as having depressive symptoms using the Korean version of the Beck Depression Inventory (BDI) with a cut-off ≥16, and categorised into four groups. Multivariable logistic regression analyses were performed to identify independent risk factors for depression defined as a BDI score ≥16.

RESULTS: Of the 505 patients, 97 (19.2%) were diagnosed with depression. Patients with a higher BDI score were older, more likely to be a current smoker, and had a SLICC score >1. Conversely, they had lower income and educational levels. Regarding the serologic findings, patients with a higher BDI score had lower anti-double-stranded DNA positivity and higher anticardiolipin (aCL) positivity. On multivariate analysis, the following factors were associated with depression: current smoking status (OR 2.533, p=0.049), aCL-positivity (OR 2.009, p=0.035), and a SLICC damage index score >1 (OR 2.781, p=0.039). On the other hand, high-level education (OR 0.253, p=0.024) and a high income (OR 0.228, p=0.008) were negatively associated with depression.

CONCLUSIONS: Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE.

Original languageEnglish
Pages (from-to)627-635
Number of pages9
JournalClinical and Experimental Rheumatology
Volume36
Issue number4
Publication statusPublished - 2018 Jul 1

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Anticardiolipin Antibodies
Social Class
Systemic Lupus Erythematosus
Registries
Depression
Equipment and Supplies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus : results from the KORNET registry. / Park, Dong Jin; Kang, Ji Hyoun; Lee, Kyung Eun; Kang, Seong Wook; Kwok, Seung Ki; Kim, Seong Kyu; Choe, Jung Yoon; Kim, Hyoun Ah; Sung, Yoon Kyoung; Shin, Kichul; Lee, Sang Il; Lee, Chang Hoon; Choi, Sungjae; Lee, Shin Seok.

In: Clinical and Experimental Rheumatology, Vol. 36, No. 4, 01.07.2018, p. 627-635.

Research output: Contribution to journalArticle

Park, DJ, Kang, JH, Lee, KE, Kang, SW, Kwok, SK, Kim, SK, Choe, JY, Kim, HA, Sung, YK, Shin, K, Lee, SI, Lee, CH, Choi, S & Lee, SS 2018, 'Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry', Clinical and Experimental Rheumatology, vol. 36, no. 4, pp. 627-635.
Park, Dong Jin ; Kang, Ji Hyoun ; Lee, Kyung Eun ; Kang, Seong Wook ; Kwok, Seung Ki ; Kim, Seong Kyu ; Choe, Jung Yoon ; Kim, Hyoun Ah ; Sung, Yoon Kyoung ; Shin, Kichul ; Lee, Sang Il ; Lee, Chang Hoon ; Choi, Sungjae ; Lee, Shin Seok. / Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus : results from the KORNET registry. In: Clinical and Experimental Rheumatology. 2018 ; Vol. 36, No. 4. pp. 627-635.
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abstract = "OBJECTIVES: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients.METHODS: In this study, 505 consecutive SLE patients were enrolled from the Korean Lupus Network registry. Demographic variables, clinical manifestations, laboratory findings, physician global assessment, and SLEDAI-2000 and SLICC damage index were recorded at enrolment. Patients were identified as having depressive symptoms using the Korean version of the Beck Depression Inventory (BDI) with a cut-off ≥16, and categorised into four groups. Multivariable logistic regression analyses were performed to identify independent risk factors for depression defined as a BDI score ≥16.RESULTS: Of the 505 patients, 97 (19.2{\%}) were diagnosed with depression. Patients with a higher BDI score were older, more likely to be a current smoker, and had a SLICC score >1. Conversely, they had lower income and educational levels. Regarding the serologic findings, patients with a higher BDI score had lower anti-double-stranded DNA positivity and higher anticardiolipin (aCL) positivity. On multivariate analysis, the following factors were associated with depression: current smoking status (OR 2.533, p=0.049), aCL-positivity (OR 2.009, p=0.035), and a SLICC damage index score >1 (OR 2.781, p=0.039). On the other hand, high-level education (OR 0.253, p=0.024) and a high income (OR 0.228, p=0.008) were negatively associated with depression.CONCLUSIONS: Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE.",
author = "Park, {Dong Jin} and Kang, {Ji Hyoun} and Lee, {Kyung Eun} and Kang, {Seong Wook} and Kwok, {Seung Ki} and Kim, {Seong Kyu} and Choe, {Jung Yoon} and Kim, {Hyoun Ah} and Sung, {Yoon Kyoung} and Kichul Shin and Lee, {Sang Il} and Lee, {Chang Hoon} and Sungjae Choi and Lee, {Shin Seok}",
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T1 - Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus

T2 - results from the KORNET registry

AU - Park, Dong Jin

AU - Kang, Ji Hyoun

AU - Lee, Kyung Eun

AU - Kang, Seong Wook

AU - Kwok, Seung Ki

AU - Kim, Seong Kyu

AU - Choe, Jung Yoon

AU - Kim, Hyoun Ah

AU - Sung, Yoon Kyoung

AU - Shin, Kichul

AU - Lee, Sang Il

AU - Lee, Chang Hoon

AU - Choi, Sungjae

AU - Lee, Shin Seok

PY - 2018/7/1

Y1 - 2018/7/1

N2 - OBJECTIVES: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients.METHODS: In this study, 505 consecutive SLE patients were enrolled from the Korean Lupus Network registry. Demographic variables, clinical manifestations, laboratory findings, physician global assessment, and SLEDAI-2000 and SLICC damage index were recorded at enrolment. Patients were identified as having depressive symptoms using the Korean version of the Beck Depression Inventory (BDI) with a cut-off ≥16, and categorised into four groups. Multivariable logistic regression analyses were performed to identify independent risk factors for depression defined as a BDI score ≥16.RESULTS: Of the 505 patients, 97 (19.2%) were diagnosed with depression. Patients with a higher BDI score were older, more likely to be a current smoker, and had a SLICC score >1. Conversely, they had lower income and educational levels. Regarding the serologic findings, patients with a higher BDI score had lower anti-double-stranded DNA positivity and higher anticardiolipin (aCL) positivity. On multivariate analysis, the following factors were associated with depression: current smoking status (OR 2.533, p=0.049), aCL-positivity (OR 2.009, p=0.035), and a SLICC damage index score >1 (OR 2.781, p=0.039). On the other hand, high-level education (OR 0.253, p=0.024) and a high income (OR 0.228, p=0.008) were negatively associated with depression.CONCLUSIONS: Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE.

AB - OBJECTIVES: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients.METHODS: In this study, 505 consecutive SLE patients were enrolled from the Korean Lupus Network registry. Demographic variables, clinical manifestations, laboratory findings, physician global assessment, and SLEDAI-2000 and SLICC damage index were recorded at enrolment. Patients were identified as having depressive symptoms using the Korean version of the Beck Depression Inventory (BDI) with a cut-off ≥16, and categorised into four groups. Multivariable logistic regression analyses were performed to identify independent risk factors for depression defined as a BDI score ≥16.RESULTS: Of the 505 patients, 97 (19.2%) were diagnosed with depression. Patients with a higher BDI score were older, more likely to be a current smoker, and had a SLICC score >1. Conversely, they had lower income and educational levels. Regarding the serologic findings, patients with a higher BDI score had lower anti-double-stranded DNA positivity and higher anticardiolipin (aCL) positivity. On multivariate analysis, the following factors were associated with depression: current smoking status (OR 2.533, p=0.049), aCL-positivity (OR 2.009, p=0.035), and a SLICC damage index score >1 (OR 2.781, p=0.039). On the other hand, high-level education (OR 0.253, p=0.024) and a high income (OR 0.228, p=0.008) were negatively associated with depression.CONCLUSIONS: Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE.

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