Assoziation von eNOS-Polymorphismen mit der Suszeptibilität für Femurkopfnekrosen: Eine Metaanalyse

Translated title of the contribution: Association of eNOS polymorphisms with susceptibility to osteonecrosis of the femur head: A meta-analysis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The aim of the present study was to determine whether polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are associated with susceptibility to osteonecrosis of the femoral head (ONFH). Methods: We conducted a meta-analysis to assess the association between the 4b/a, G894T, and T786C polymorphisms of eNOS and the susceptibility to ONFH. Results: A total of five studies, which included 566 cases and 833 controls, were included in the meta-analysis. Meta-analysis revealed a significant association between allele a of the 4b/a polymorphism and ONFH in all study subjects (odds ratio, OR 3.237; 95 % confidence interval, CI 2.036–5.148; P = 6.9 × 10−7); stratification by ethnicity indicated an association between this allele and ONFH in Caucasians and Asians (OR 2.985; 95 % CI 1.592–5.597; P = 0.001 and OR 3.567; 95 % CI 1.793–7.095; P = 2.9 × 10−4, respectively). Meta-analysis stratified by ONFH type showed a significant association between allele a of the 4b/a polymorphism and idiopathic and secondary ONFH (OR 3.411; 95 % CI 2.049–5.679; P = 2.4 × 10−6 and OR 3.163; 95 % CI 1.781–5.619, P = 8.6 × 10 −5, respectively). However, the meta-analysis did not show any allelic association between the G894T and T786C polymorphisms and ONFH (OR 1.718; 95 % CI 0.796–3.707; P = 0.168 and OR 1.027; 95 % CI 0.191–5.517; P = 0.976, respectively). Conclusion: Our meta-analysis of published studies shows that the 4b/a polymorphism is associated with the development of idiopathic and secondary ONFH in Caucasians and Asians.

Original languageGerman
Pages (from-to)267-273
Number of pages7
JournalZeitschrift fur Rheumatologie
Volume76
Issue number3
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

Femur Head
Osteonecrosis
Nitric Oxide Synthase Type III
Thigh
Meta-Analysis
Alleles
Odds Ratio
Confidence Intervals

Keywords

  • Confidence Interval
  • Endothelial nitric oxide synthase
  • Meta-analysis
  • Osteonecrosis
  • Polymorphism

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{d8a4de81690b438abd094f5f91fd545e,
title = "Assoziation von eNOS-Polymorphismen mit der Suszeptibilit{\"a}t f{\"u}r Femurkopfnekrosen: Eine Metaanalyse",
abstract = "Objective: The aim of the present study was to determine whether polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are associated with susceptibility to osteonecrosis of the femoral head (ONFH). Methods: We conducted a meta-analysis to assess the association between the 4b/a, G894T, and T786C polymorphisms of eNOS and the susceptibility to ONFH. Results: A total of five studies, which included 566 cases and 833 controls, were included in the meta-analysis. Meta-analysis revealed a significant association between allele a of the 4b/a polymorphism and ONFH in all study subjects (odds ratio, OR 3.237; 95 {\%} confidence interval, CI 2.036–5.148; P = 6.9 × 10−7); stratification by ethnicity indicated an association between this allele and ONFH in Caucasians and Asians (OR 2.985; 95 {\%} CI 1.592–5.597; P = 0.001 and OR 3.567; 95 {\%} CI 1.793–7.095; P = 2.9 × 10−4, respectively). Meta-analysis stratified by ONFH type showed a significant association between allele a of the 4b/a polymorphism and idiopathic and secondary ONFH (OR 3.411; 95 {\%} CI 2.049–5.679; P = 2.4 × 10−6 and OR 3.163; 95 {\%} CI 1.781–5.619, P = 8.6 × 10 −5, respectively). However, the meta-analysis did not show any allelic association between the G894T and T786C polymorphisms and ONFH (OR 1.718; 95 {\%} CI 0.796–3.707; P = 0.168 and OR 1.027; 95 {\%} CI 0.191–5.517; P = 0.976, respectively). Conclusion: Our meta-analysis of published studies shows that the 4b/a polymorphism is associated with the development of idiopathic and secondary ONFH in Caucasians and Asians.",
keywords = "Confidence Interval, Endothelial nitric oxide synthase, Meta-analysis, Osteonecrosis, Polymorphism",
author = "Song, {Gwan Gyu} and Lee, {Young Ho}",
year = "2017",
month = "4",
day = "1",
doi = "10.1007/s00393-016-0093-3",
language = "German",
volume = "76",
pages = "267--273",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
publisher = "D. Steinkopff-Verlag",
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}

TY - JOUR

T1 - Assoziation von eNOS-Polymorphismen mit der Suszeptibilität für Femurkopfnekrosen

T2 - Eine Metaanalyse

AU - Song, Gwan Gyu

AU - Lee, Young Ho

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective: The aim of the present study was to determine whether polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are associated with susceptibility to osteonecrosis of the femoral head (ONFH). Methods: We conducted a meta-analysis to assess the association between the 4b/a, G894T, and T786C polymorphisms of eNOS and the susceptibility to ONFH. Results: A total of five studies, which included 566 cases and 833 controls, were included in the meta-analysis. Meta-analysis revealed a significant association between allele a of the 4b/a polymorphism and ONFH in all study subjects (odds ratio, OR 3.237; 95 % confidence interval, CI 2.036–5.148; P = 6.9 × 10−7); stratification by ethnicity indicated an association between this allele and ONFH in Caucasians and Asians (OR 2.985; 95 % CI 1.592–5.597; P = 0.001 and OR 3.567; 95 % CI 1.793–7.095; P = 2.9 × 10−4, respectively). Meta-analysis stratified by ONFH type showed a significant association between allele a of the 4b/a polymorphism and idiopathic and secondary ONFH (OR 3.411; 95 % CI 2.049–5.679; P = 2.4 × 10−6 and OR 3.163; 95 % CI 1.781–5.619, P = 8.6 × 10 −5, respectively). However, the meta-analysis did not show any allelic association between the G894T and T786C polymorphisms and ONFH (OR 1.718; 95 % CI 0.796–3.707; P = 0.168 and OR 1.027; 95 % CI 0.191–5.517; P = 0.976, respectively). Conclusion: Our meta-analysis of published studies shows that the 4b/a polymorphism is associated with the development of idiopathic and secondary ONFH in Caucasians and Asians.

AB - Objective: The aim of the present study was to determine whether polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are associated with susceptibility to osteonecrosis of the femoral head (ONFH). Methods: We conducted a meta-analysis to assess the association between the 4b/a, G894T, and T786C polymorphisms of eNOS and the susceptibility to ONFH. Results: A total of five studies, which included 566 cases and 833 controls, were included in the meta-analysis. Meta-analysis revealed a significant association between allele a of the 4b/a polymorphism and ONFH in all study subjects (odds ratio, OR 3.237; 95 % confidence interval, CI 2.036–5.148; P = 6.9 × 10−7); stratification by ethnicity indicated an association between this allele and ONFH in Caucasians and Asians (OR 2.985; 95 % CI 1.592–5.597; P = 0.001 and OR 3.567; 95 % CI 1.793–7.095; P = 2.9 × 10−4, respectively). Meta-analysis stratified by ONFH type showed a significant association between allele a of the 4b/a polymorphism and idiopathic and secondary ONFH (OR 3.411; 95 % CI 2.049–5.679; P = 2.4 × 10−6 and OR 3.163; 95 % CI 1.781–5.619, P = 8.6 × 10 −5, respectively). However, the meta-analysis did not show any allelic association between the G894T and T786C polymorphisms and ONFH (OR 1.718; 95 % CI 0.796–3.707; P = 0.168 and OR 1.027; 95 % CI 0.191–5.517; P = 0.976, respectively). Conclusion: Our meta-analysis of published studies shows that the 4b/a polymorphism is associated with the development of idiopathic and secondary ONFH in Caucasians and Asians.

KW - Confidence Interval

KW - Endothelial nitric oxide synthase

KW - Meta-analysis

KW - Osteonecrosis

KW - Polymorphism

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U2 - 10.1007/s00393-016-0093-3

DO - 10.1007/s00393-016-0093-3

M3 - Article

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