TY - JOUR
T1 - Association of G-protein β3 subunit C825T polymorphism with seasonal variations in mood and behavior
AU - Nam, Yoon Ju
AU - Cho, Chul Hyun
AU - Kim, Leen
AU - Lee, Heon Jeong
N1 - Funding Information:
This study was supported by the Korea Health 21 R&D Project that was funded by the National Research Foundation of Korea (2016M3C7A190 4345), and the Ministry of Health & Welfare, Republic of Korea (HI1 4C2750) and the grant (Grant No. K1620091) from Korea University Anam Hospital, Seoul, Republic of Korea.
PY - 2018/2
Y1 - 2018/2
N2 - Objective Seasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Korean population. Methods A total of 507 young Korean participants were recruited through a newspaper advertisement, and their seasonality was evaluated by the Korean version of the Seasonal Pattern Assessment Questionnaire to assess the global seasonality score (GSS). We analyzed the CC, CT, and TT genotypes and their association with the GSS score and subscales. Results T allele carriers of the GNB3 C825T polymorphism were more likely to score higher on body weight and GSS. In the female group, the T allele carriers obtained significantly high total GSS and its subscale scores for mood, body weight, energy level, and appetite; however, differences in genotypes and allele carriers were also observed in the male sparticipants. Conclusion These results suggested that GNB3 C825T polymorphism plays a role inlles.
AB - Objective Seasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Korean population. Methods A total of 507 young Korean participants were recruited through a newspaper advertisement, and their seasonality was evaluated by the Korean version of the Seasonal Pattern Assessment Questionnaire to assess the global seasonality score (GSS). We analyzed the CC, CT, and TT genotypes and their association with the GSS score and subscales. Results T allele carriers of the GNB3 C825T polymorphism were more likely to score higher on body weight and GSS. In the female group, the T allele carriers obtained significantly high total GSS and its subscale scores for mood, body weight, energy level, and appetite; however, differences in genotypes and allele carriers were also observed in the male sparticipants. Conclusion These results suggested that GNB3 C825T polymorphism plays a role inlles.
KW - GNB3
KW - Genetic association
KW - Seasonal affective disorder
KW - Seasonality
UR - http://www.scopus.com/inward/record.url?scp=85042525048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042525048&partnerID=8YFLogxK
U2 - 10.30773/pi.2017.09.21
DO - 10.30773/pi.2017.09.21
M3 - Article
AN - SCOPUS:85042525048
VL - 15
SP - 200
EP - 204
JO - Psychiatry Investigation
JF - Psychiatry Investigation
SN - 1738-3684
IS - 2
ER -