Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease

Hye-Jin Yoo, S. Y. Hwang, Geum-Joon Cho, H. C. Hong, H. Y. Choi, T. G. Hwang, Seon Mee Kim, Matthias Blüher, Byung Soo Youn, Sei-Hyun Baik, Kyung Mook Choi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Context and Objective: Glypican-4 was identified as a novel adipokine capable of enhancing insulin signaling and modulating adipocyte differentiation. We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects. Design and Participants: We analyzed baseline cross-sectional data from the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. NAFLD was diagnosed by unenhanced computed tomography using the liver attenuation index. We also examined the effects of a 3-month combined aerobic and resistance exercise program on glypican-4 levels and cardiometabolic risk factors. Results: Circulating glypican-4 levels were higher in men than in women (1.83 [1.19, 2.78] ng/mL vs 1.17 [0.66, 2.00] ng/mL, P < .001) and had a significant positive relationship with the waist-to-hip ratio (WHR) (r = 0.20, P = .014) and the ratio of visceral to sc fat area (r = 0.30, P < .001). Furthermore, glypican-4 levels in women were correlated with cardiometabolic risk factors, including insulin resistance and arterial stiffness, and were independently associated with NAFLD by multiple logistic regression analysis (P = .017, R2= 0.33). The 3-month combined exercise training program significantly improved several cardiometabolic parameters and reduced retinol binding protein-4 levels. Changes in glypican-4 levels after the exercise program were significantly different between subjects with an increased WHR compared with those with a decreased WHR (P = .034). Conclusion: A gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness.

Original languageEnglish
Pages (from-to)2897-2901
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Glypicans
Body Fat Distribution
Liver
Insulin Resistance
Fats
Insulin
Vascular Stiffness
Waist-Hip Ratio
Stiffness
Exercise
Retinol-Binding Proteins
Adipokines
Non-alcoholic Fatty Liver Disease
Body Composition
Adipocytes
Regression analysis
Tomography
Logistics
Cohort Studies
Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. / Yoo, Hye-Jin; Hwang, S. Y.; Cho, Geum-Joon; Hong, H. C.; Choi, H. Y.; Hwang, T. G.; Kim, Seon Mee; Blüher, Matthias; Youn, Byung Soo; Baik, Sei-Hyun; Choi, Kyung Mook.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 7, 01.07.2013, p. 2897-2901.

Research output: Contribution to journalArticle

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abstract = "Context and Objective: Glypican-4 was identified as a novel adipokine capable of enhancing insulin signaling and modulating adipocyte differentiation. We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects. Design and Participants: We analyzed baseline cross-sectional data from the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. NAFLD was diagnosed by unenhanced computed tomography using the liver attenuation index. We also examined the effects of a 3-month combined aerobic and resistance exercise program on glypican-4 levels and cardiometabolic risk factors. Results: Circulating glypican-4 levels were higher in men than in women (1.83 [1.19, 2.78] ng/mL vs 1.17 [0.66, 2.00] ng/mL, P < .001) and had a significant positive relationship with the waist-to-hip ratio (WHR) (r = 0.20, P = .014) and the ratio of visceral to sc fat area (r = 0.30, P < .001). Furthermore, glypican-4 levels in women were correlated with cardiometabolic risk factors, including insulin resistance and arterial stiffness, and were independently associated with NAFLD by multiple logistic regression analysis (P = .017, R2= 0.33). The 3-month combined exercise training program significantly improved several cardiometabolic parameters and reduced retinol binding protein-4 levels. Changes in glypican-4 levels after the exercise program were significantly different between subjects with an increased WHR compared with those with a decreased WHR (P = .034). Conclusion: A gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness.",
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AU - Hong, H. C.

AU - Choi, H. Y.

AU - Hwang, T. G.

AU - Kim, Seon Mee

AU - Blüher, Matthias

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AU - Choi, Kyung Mook

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