Association of inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis as assessed by biomarkers and echocardiography

Ji Young Park, Sung Kee Ryu, Jae Woong Choi, Kim Min Ho, Jin Hyun Jun, Seung-Woon Rha, Seong-Mi Park, Hyo Jeong Kim, Byoung Geol Choi, Yung Kyun Noh, Seungwhan Kim

Research output: Contribution to journalArticle

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Abstract

The aim of the present study was to investigate the relationships among inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis (AS), as assessed by biomarkers and echocardiography. We evaluated 32 consecutive patients with mild AS, as well as 30 age- and gender-matched healthy individuals with normal aortic valves as control subjects. Baseline echocardiography showed that the left ventricular (LV) mass index (111.3 ± 26.9 vs 94.5 ± 18.2 g/m2; P = 0.006) and left atrial (LA) volume index (LAVI 27.5 ± 9.0 vs xx.x ± 5.2 mm3/mm2; P = 0.005) were significantly higher in patients with mild AS. Furthermore, LA enlargement (LAVI > 33 mm3/mm2; 32.4% vs 3.3%;P = 0.003) and elevated LV filling pressure (E/e′ > 15; 50.0% vs 23.3%; P = 0.036) were higher in patients with mild AS. In patients with mild AS, stepwise, multivariate linear regression analysis revealed that the LV end-diastolic volume index was independently associated with matrix metalloproteinase (MMP)-1 (β = 0.371; P = 0.015), that the aortic valve mean pressure gradient was independently associated with MMP-2 (β = 0.19; P = 0.019), that MMP-2 was independently associated with transforming growth factor-β (β = 0.95; P < 0.001) and interleukin (IL)-1 (β = 0.17; P = 0.019) and that IL-1 was independently associated with tissue inhibitor of matrix metalloproteinase-1 (β = 0.68; P = 0.001). Myocardial fibrosis in mild AS is independently associated with three factors: LV volume overload, aortic valve pressure overload and inflammation.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume41
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Aortic Valve Stenosis
Echocardiography
Fibrosis
Biomarkers
Inflammation
Aortic Valve
Matrix Metalloproteinase 1
Matrix Metalloproteinase 2
Interleukin-1
Tissue Inhibitor of Metalloproteinase-1
Transforming Growth Factors
Ventricular Pressure
Stroke Volume
Linear Models
Arterial Pressure
Regression Analysis
Pressure

Keywords

  • Aortic stenosis
  • Echocardiography
  • Inflammation
  • Myocardial fibrosis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

Cite this

Association of inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis as assessed by biomarkers and echocardiography. / Park, Ji Young; Ryu, Sung Kee; Choi, Jae Woong; Ho, Kim Min; Jun, Jin Hyun; Rha, Seung-Woon; Park, Seong-Mi; Kim, Hyo Jeong; Choi, Byoung Geol; Noh, Yung Kyun; Kim, Seungwhan.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 41, No. 3, 01.01.2014, p. 185-191.

Research output: Contribution to journalArticle

Park, Ji Young ; Ryu, Sung Kee ; Choi, Jae Woong ; Ho, Kim Min ; Jun, Jin Hyun ; Rha, Seung-Woon ; Park, Seong-Mi ; Kim, Hyo Jeong ; Choi, Byoung Geol ; Noh, Yung Kyun ; Kim, Seungwhan. / Association of inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis as assessed by biomarkers and echocardiography. In: Clinical and Experimental Pharmacology and Physiology. 2014 ; Vol. 41, No. 3. pp. 185-191.
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AU - Jun, Jin Hyun

AU - Rha, Seung-Woon

AU - Park, Seong-Mi

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