Association of Insulin-Like Growth Factor-I (IGF-I) Gene Polymorphism with Serum IGF-I Concentration and Body Weight in Korean Native Ogol Chicken

D. S. Seo, J. S. Yun, W. J. Kang, G. J. Jeon, Ki Chang Hong, Yong Ko

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

IGF-I is involved in the regulation of growth and differentiation in mammals, but its role as a modulator of growth and metabolism in poultry is poorly understood. And. no studies have so far been reported for the comparison between serum IGF-I concentration and body growth in the egg type or the dual purposes (meat and egg type) chicken including the Korean Native Ogol Chicken (KNOC). Therefore, in order to improve the body growth and meat production of the KNOC, this study was conducted for the identification of the polymorphism of IGF-I gene and for its possible association with both body weight and IGF-I concentration. The RFLP patterns for IGF-I gene were identified by the Pstl restriction enzyme. The frequencies of +/+, +/-, and -/- genotype were 16.9%, 51.7%, and 31.4%, respectively. Any statistical significance was not observed in all variations except for sex variation (p<0.01) by covariate quadratic model. The significant effect of the IGF-I genotype on body weight by sex indicates that there are different physiological characteristics in gender. Although the body weights of male KNOCs in most ages were not significant, there was a tendency of KNOCs with +/+ IGF-I genotype to be heavier than those with any other genotypes. But all IGF-I genotypes in female did not influence on body weight. The ANOVA revealed no significant effects of IGF-I genotypes on serum IGF-I concentration but sex effect was highly significant on the IGF-I concentration at 20 and 40 weeks (p<0.01). Although the +/+ genotype, in gender, tended to express a higher IGF-I concentration than the other genotypes at all ages in males, a statistical difference among the genotypes was not found except for 60 weeks (p<0.05). Furthermore, since body weight and IGF-I genotypes are associated, it is possible to improve KNOC to a meat type breed if a continuous selection can be made for the body weight and/or IGF-I traits.

Original languageEnglish
Pages (from-to)915-921
Number of pages7
JournalAsian-Australasian Journal of Animal Sciences
Volume14
Issue number7
Publication statusPublished - 2001 Jul 1

Fingerprint

insulin-like growth factor I
Insulin-Like Growth Factor I
Chickens
Body Weight
genetic polymorphism
chickens
body weight
Genotype
Serum
Genes
genotype
genes
gender
Meat
Growth
Ovum
meat
meat production
Poultry
Restriction Fragment Length Polymorphisms

Keywords

  • Body Weight
  • IGF-I
  • Korean Native Ogol Chicken
  • RFLP

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Association of Insulin-Like Growth Factor-I (IGF-I) Gene Polymorphism with Serum IGF-I Concentration and Body Weight in Korean Native Ogol Chicken. / Seo, D. S.; Yun, J. S.; Kang, W. J.; Jeon, G. J.; Hong, Ki Chang; Ko, Yong.

In: Asian-Australasian Journal of Animal Sciences, Vol. 14, No. 7, 01.07.2001, p. 915-921.

Research output: Contribution to journalArticle

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abstract = "IGF-I is involved in the regulation of growth and differentiation in mammals, but its role as a modulator of growth and metabolism in poultry is poorly understood. And. no studies have so far been reported for the comparison between serum IGF-I concentration and body growth in the egg type or the dual purposes (meat and egg type) chicken including the Korean Native Ogol Chicken (KNOC). Therefore, in order to improve the body growth and meat production of the KNOC, this study was conducted for the identification of the polymorphism of IGF-I gene and for its possible association with both body weight and IGF-I concentration. The RFLP patterns for IGF-I gene were identified by the Pstl restriction enzyme. The frequencies of +/+, +/-, and -/- genotype were 16.9{\%}, 51.7{\%}, and 31.4{\%}, respectively. Any statistical significance was not observed in all variations except for sex variation (p<0.01) by covariate quadratic model. The significant effect of the IGF-I genotype on body weight by sex indicates that there are different physiological characteristics in gender. Although the body weights of male KNOCs in most ages were not significant, there was a tendency of KNOCs with +/+ IGF-I genotype to be heavier than those with any other genotypes. But all IGF-I genotypes in female did not influence on body weight. The ANOVA revealed no significant effects of IGF-I genotypes on serum IGF-I concentration but sex effect was highly significant on the IGF-I concentration at 20 and 40 weeks (p<0.01). Although the +/+ genotype, in gender, tended to express a higher IGF-I concentration than the other genotypes at all ages in males, a statistical difference among the genotypes was not found except for 60 weeks (p<0.05). Furthermore, since body weight and IGF-I genotypes are associated, it is possible to improve KNOC to a meat type breed if a continuous selection can be made for the body weight and/or IGF-I traits.",
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