Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)

Hyun T. Park, Geum J. Cho, Ki H. Ahn, Jung H. Shin, Young T. Kim, Jun Y. Hur, Sun H. Kim, Kyu W. Lee, Tak Kim

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)

    Abstract

    Objective To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS). Design/patients/measurements We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles. Results Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH. Conclusion An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.

    Original languageEnglish
    Pages (from-to)26-31
    Number of pages6
    JournalClinical Endocrinology
    Volume72
    Issue number1
    DOIs
    Publication statusPublished - 2010 Jan

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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