Association of lipid parameters and insulin resistance with bone health in South Korean adolescents

S. W. Park, G. E. Nam, D. W. Jung, S. J. Yoon, K. Han, Y. G. Park, J. S. Choi, J. E. Lee, J. E. Sang, Y. J. Yoon, Do-Hoon Kim

Research output: Contribution to journalArticle

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Abstract

Summary: This study investigated the association between lipid profiles and insulin resistance and bone mineral content (BMC) in Korean adolescents and found that BMC was inversely associated with triglyceride (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). This association did not differ according to obesity status in either boys or girls. Introduction: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the association between lipid profiles and insulin resistance and BMC in Korean adolescents. Methods: Data from 706 boys and 621 girls, who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011, were analyzed. Lipid profiles were measured, and HOMA-IR was calculated to assess insulin resistance. BMC was measured for the total femur, femur neck, and lumbar spine by using whole-body dual-energy X-ray absorptiometry (DXA). Results: TG level and HOMA-IR were negatively correlated with BMC at all three sites in boys. In girls, TG level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC at the femur neck only. These inverse associations did not differ according to obesity status in either sex. Adjusted means of BMC at the three sites in boys tended to decrease in the higher tertile groups of TG and HOMA-IR, and the adjusted means of BMC for the total femur in girls tended to decrease in the higher tertile groups of TG and HOMA-IR. Conclusions: BMC was inversely associated with TG and HOMA-IR in Korean adolescents, and this association was more pronounced in boys. This association did not differ according to obesity status in either sex.

Original languageEnglish
Pages (from-to)635-642
Number of pages8
JournalOsteoporosis International
Volume27
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Fingerprint

Bone Density
Insulin Resistance
Lipids
Bone and Bones
Homeostasis
Health
Triglycerides
Femur Neck
Obesity
Femur
Spine
Nutrition Surveys
Photon Absorptiometry
Korea
Osteoporosis

Keywords

  • Adolescence
  • Bone mineral content
  • Insulin resistance
  • Korean
  • Lipid profile

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Association of lipid parameters and insulin resistance with bone health in South Korean adolescents. / Park, S. W.; Nam, G. E.; Jung, D. W.; Yoon, S. J.; Han, K.; Park, Y. G.; Choi, J. S.; Lee, J. E.; Sang, J. E.; Yoon, Y. J.; Kim, Do-Hoon.

In: Osteoporosis International, Vol. 27, No. 2, 01.02.2016, p. 635-642.

Research output: Contribution to journalArticle

Park, SW, Nam, GE, Jung, DW, Yoon, SJ, Han, K, Park, YG, Choi, JS, Lee, JE, Sang, JE, Yoon, YJ & Kim, D-H 2016, 'Association of lipid parameters and insulin resistance with bone health in South Korean adolescents', Osteoporosis International, vol. 27, no. 2, pp. 635-642. https://doi.org/10.1007/s00198-015-3306-8
Park, S. W. ; Nam, G. E. ; Jung, D. W. ; Yoon, S. J. ; Han, K. ; Park, Y. G. ; Choi, J. S. ; Lee, J. E. ; Sang, J. E. ; Yoon, Y. J. ; Kim, Do-Hoon. / Association of lipid parameters and insulin resistance with bone health in South Korean adolescents. In: Osteoporosis International. 2016 ; Vol. 27, No. 2. pp. 635-642.
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abstract = "Summary: This study investigated the association between lipid profiles and insulin resistance and bone mineral content (BMC) in Korean adolescents and found that BMC was inversely associated with triglyceride (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). This association did not differ according to obesity status in either boys or girls. Introduction: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the association between lipid profiles and insulin resistance and BMC in Korean adolescents. Methods: Data from 706 boys and 621 girls, who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011, were analyzed. Lipid profiles were measured, and HOMA-IR was calculated to assess insulin resistance. BMC was measured for the total femur, femur neck, and lumbar spine by using whole-body dual-energy X-ray absorptiometry (DXA). Results: TG level and HOMA-IR were negatively correlated with BMC at all three sites in boys. In girls, TG level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC at the femur neck only. These inverse associations did not differ according to obesity status in either sex. Adjusted means of BMC at the three sites in boys tended to decrease in the higher tertile groups of TG and HOMA-IR, and the adjusted means of BMC for the total femur in girls tended to decrease in the higher tertile groups of TG and HOMA-IR. Conclusions: BMC was inversely associated with TG and HOMA-IR in Korean adolescents, and this association was more pronounced in boys. This association did not differ according to obesity status in either sex.",
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T1 - Association of lipid parameters and insulin resistance with bone health in South Korean adolescents

AU - Park, S. W.

AU - Nam, G. E.

AU - Jung, D. W.

AU - Yoon, S. J.

AU - Han, K.

AU - Park, Y. G.

AU - Choi, J. S.

AU - Lee, J. E.

AU - Sang, J. E.

AU - Yoon, Y. J.

AU - Kim, Do-Hoon

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N2 - Summary: This study investigated the association between lipid profiles and insulin resistance and bone mineral content (BMC) in Korean adolescents and found that BMC was inversely associated with triglyceride (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). This association did not differ according to obesity status in either boys or girls. Introduction: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the association between lipid profiles and insulin resistance and BMC in Korean adolescents. Methods: Data from 706 boys and 621 girls, who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011, were analyzed. Lipid profiles were measured, and HOMA-IR was calculated to assess insulin resistance. BMC was measured for the total femur, femur neck, and lumbar spine by using whole-body dual-energy X-ray absorptiometry (DXA). Results: TG level and HOMA-IR were negatively correlated with BMC at all three sites in boys. In girls, TG level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC at the femur neck only. These inverse associations did not differ according to obesity status in either sex. Adjusted means of BMC at the three sites in boys tended to decrease in the higher tertile groups of TG and HOMA-IR, and the adjusted means of BMC for the total femur in girls tended to decrease in the higher tertile groups of TG and HOMA-IR. Conclusions: BMC was inversely associated with TG and HOMA-IR in Korean adolescents, and this association was more pronounced in boys. This association did not differ according to obesity status in either sex.

AB - Summary: This study investigated the association between lipid profiles and insulin resistance and bone mineral content (BMC) in Korean adolescents and found that BMC was inversely associated with triglyceride (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). This association did not differ according to obesity status in either boys or girls. Introduction: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the association between lipid profiles and insulin resistance and BMC in Korean adolescents. Methods: Data from 706 boys and 621 girls, who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011, were analyzed. Lipid profiles were measured, and HOMA-IR was calculated to assess insulin resistance. BMC was measured for the total femur, femur neck, and lumbar spine by using whole-body dual-energy X-ray absorptiometry (DXA). Results: TG level and HOMA-IR were negatively correlated with BMC at all three sites in boys. In girls, TG level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC at the femur neck only. These inverse associations did not differ according to obesity status in either sex. Adjusted means of BMC at the three sites in boys tended to decrease in the higher tertile groups of TG and HOMA-IR, and the adjusted means of BMC for the total femur in girls tended to decrease in the higher tertile groups of TG and HOMA-IR. Conclusions: BMC was inversely associated with TG and HOMA-IR in Korean adolescents, and this association was more pronounced in boys. This association did not differ according to obesity status in either sex.

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KW - Bone mineral content

KW - Insulin resistance

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KW - Lipid profile

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