Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly

Sang Yhun Ju, Juneyoung Lee, Do-Hoon Kim

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

There is increasing evidence regarding the relationship between metabolic syndrome and mortality. However, previous research examining metabolic syndrome and mortality in older populations has produced mixed results. In addition, there is a clear need to identify and manage individual components of metabolic syndrome to decrease cardiovascular disease (CVD) mortality. In this meta-analysis, we searched the MEDLINE databases using PubMed, Cochrane Library, and EMBASE databases. Based on 20 prospective cohort studies, metabolic syndrome was associated with a higher risk of all-cause mortality [relative risk (RR), 1.23; 95% confidence interval (CI), 1.15-1.32; I 2 = 55.9%] and CVD mortality (RR, 1.24; 95% CI, 1.11-1.39; I 2 = 58.1%). The risk estimates of all-cause mortality for single components of metabolic syndrome were significant for higher values of waist circumference or body mass index (RR, 0.94; 95% CI, 0.88-1.00), higher values of blood glucose (RR, 1.19; 95% CI, 1.05-1.34), and lower values of high-density lipoprotein (HDL) cholesterol (RR, 1.11; 95% CI, 1.02-1.21). In the elderly population, metabolic syndrome was associated with an increased risk of all-cause and CVD mortality. Among the individual components of metabolic syndrome, increased blood glucose and HDL cholesterol levels were significantly associated with increased mortality. However, older obese or overweight individuals may have a decreased mortality risk. Thus, the findings of the current meta-analysis raise questions about the utility of the definition of metabolic syndrome in predicting all-cause mortality and CVD mortality in the elderly population.

Original languageEnglish
Article numbere8491
JournalMedicine (United States)
Volume96
Issue number45
DOIs
Publication statusPublished - 2017 Nov 1

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Mortality
Confidence Intervals
Cardiovascular Diseases
HDL Cholesterol
Blood Glucose
Meta-Analysis
Databases
Population
Waist Circumference
PubMed
MEDLINE
Libraries
Body Mass Index
Cohort Studies
Prospective Studies
Research

Keywords

  • all-cause mortality
  • cardiovascular disease
  • cohort studies
  • meta-analysis
  • metabolic syndrome X

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly. / Ju, Sang Yhun; Lee, Juneyoung; Kim, Do-Hoon.

In: Medicine (United States), Vol. 96, No. 45, e8491, 01.11.2017.

Research output: Contribution to journalReview article

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